IRCT20120415009472N30 IRCT 2026-06-13 Iran University of Medical Sciences The effect of Sumac on rheumatoid arthritis Investigation of the Effects of Sumac Supplementation on Disease Activity, Inflammatory Markers, and Immunomodulatory Factors in Patients with Rheumatoid Arthritis 2026-06-22 anticipated 96 Recruiting https://irct.ir/trial/90701 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Supportive, Randomization description: Participants will be randomly selected from patients referred to a rheumatologist at Zarrinkoub Clinic. After meeting the eligibility criteria, participants will be randomly allocated to either the intervention or control group using block randomization generated by STATA software. Randomization will be stratified by age (20–40 years and 40–60 years) and sex to ensure comparability between the two groups. A total of 96 eligible participants will be randomly assigned to 24 blocks of four subjects each. Random block sequences (Groups A and B) will be generated using STATA software or the Sealed Envelope randomization website and provided to the researcher, Blinding description: Sumac or placebo will be coded by a third party who is unaware of the contents of the packages. None of the participants, nor the researcher or analyst, will be aware of the groups (sumac or placebo) and the type of intervention (sumac or placebo), and the packages containing the powder will be supplied by the company, as well as the placebo and sumac packages, in terms of internal and external appearance. After data analysis, the pharmaceutical company will be asked for the label title (drug or placebo) to compile the report and write the findings section. 2 Patients with Rheumatoid Arthritis. Intervention 1: Intervention group: 48 people in the group receiving 1000 mg of sumac capsules (3 per day, after each meal). Intervention 2: Control group: 48 people in the group receiving lactose placebo capsules (capsules made completely identical in appearance, color, smell, taste and without therapeutic effect, 3 per day, after each meal). Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no more information