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IRCT20241008063290N3 IRCT 2026-08-01 Iran National Science Foundation The effect of an exercise training period on cardiometabolic and renal markers in overweight/obese adults The effect of 6-week high intensity interval training using an exercise snack training on cardiometabolic and renal indicators in overweight/obese adults 2026-08-06 anticipated 60 Recruiting https://irct.ir/trial/90831 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Supportive, Randomization description: Simple randomization will be used for participant allocation. To ensure concealment, a series of opaque, sealed envelopes will be prepared. For this purpose, envelopes labeled with the name of either the exercise intervention group or the control group will be created, corresponding to the total number of subjects. After thoroughly mixing (shuffling) the envelopes, each participant will select one, and their group assignment will be recorded accordingly, Blinding description: Clinical laboratory technicians, unaware of the group allocation, will assess the blood parameters. N/A Adults who are overweight or obese. Intervention 1: Control group: Control group participants are to remain inactive throughout the study and are advised to follow their usual daily routines. Intervention 2: Intervention group 1: Two-Bout High-Intensity Interval Training: The training protocol includes 2 bouts of exercise, each containing 4 sets of 2-minute body-weight HIIT exercises at 85% of maximal heart rate (HRmax). Each set is interspersed with 1 minute and 30 seconds of active recovery (at 65% HRmax) between successive sets. Intervention 3: Intervention group 2: Six-Bout High-Intensity Interval Training: The training protocol includes 6 exercise bouts, each containing 2 sets of 80-second body-weight HIIT exercises at 85% of maximal heart rate (HRmax). Each set is interspersed with 1 minute of active recovery (at 65% HRmax) between successive sets. No - There is not a plan to make this available Justification or reason for not sharing IPD is There is no further information
public Hamid Rajabi
Faculty of Sports Sciences of Kharazmi University, Shahid Keshvari Stadium, Shahid Hesari Street, Mader Square, Tehran
Tehran Iran (Islamic Republic of) 1954812345 0098 21 88329220-3 hrajabi@khu.ac.ir Kharazmi University scientific Hamid Rajabi
Faculty of Sports Sciences of Kharazmi University, Shahid Keshvari Stadium, Shahid Hesari Street, Mader Square, Tehran
Tehran Iran (Islamic Republic of) 1954812345 0098 21 88329220-3 hrajabi@khu.ac.ir Kharazmi University Iran (Islamic Republic of) Sedentary and physically inactive adults Overweight or obese individuals Body mass index (BMI) ≥ 25 kg/m² Both men and women Aged 35–55 years In generally good health Free from any serious illness or unstable medical condition requiring physician supervision over diet or physical activity No physical limitations or restrictions affecting exercise participation 35 years 55 years Both Having acute cardiovascular disease Following specific dietary regimes With weight instability (+_5 kg) in the past 3 months Having any serious medical condition that precludes long-term participation in physical activity Pregnancy Currently adhering to a structured weight-loss program Using weight-loss medications Failure to obtain physician approval for study participation E66 Overweight and obesity Other Rehabilitation Rehabilitation Control group: Control group participants are to remain inactive throughout the study and are advised to follow their usual daily routines. Intervention group 1: Two-Bout High-Intensity Interval Training: The training protocol includes 2 bouts of exercise, each containing 4 sets of 2-minute body-weight HIIT exercises at 85% of maximal heart rate (HRmax). Each set is interspersed with 1 minute and 30 seconds of active recovery (at 65% HRmax) between successive sets. Intervention group 2: Six-Bout High-Intensity Interval Training: The training protocol includes 6 exercise bouts, each containing 2 sets of 80-second body-weight HIIT exercises at 85% of maximal heart rate (HRmax). Each set is interspersed with 1 minute of active recovery (at 65% HRmax) between successive sets. Cardiometabolic index. Timepoint: 24–48 hours before and after the intervention. Method of measurement: By means of the formula. Visceral adiposity index. Timepoint: 24–48 hours before and after the intervention. Method of measurement: By means of the formula. Lipid accumulation product. Timepoint: 24–48 hours before and after the intervention. Method of measurement: By means of the formula. Triglyceride. Timepoint: 24–48 hours before and after the intervention. Method of measurement: By ELISA or enzymatic laboratory method. High-density lipoprotein. Timepoint: 24–48 hours before and after the intervention. Method of measurement: By ELISA or enzymatic laboratory method. Low-density lipoprotein. Timepoint: 24–48 hours before and after the intervention. Method of measurement: By ELISA or enzymatic laboratory method. Total cholesterol. Timepoint: 24–48 hours before and after the intervention. Method of measurement: By ELISA or enzymatic laboratory method. The ratio of high-density lipoprotein to low-density lipoprotein. Timepoint: 24–48 hours before and after the intervention. Method of measurement: By means of the formula. Thyroid-Stimulating Hormone. Timepoint: 24–48 hours before and after the intervention. Method of measurement: By ELISA or enzymatic laboratory method. Thyroxine. Timepoint: 24–48 hours before and after the intervention. Method of measurement: By ELISA or enzymatic laboratory method. Bilirubin. Timepoint: 24–48 hours before and after the intervention. Method of measurement: By ELISA or enzymatic laboratory method. Urea. Timepoint: 24–48 hours before and after the intervention. Method of measurement: By ELISA or enzymatic laboratory method. Uric acid. Timepoint: 24–48 hours before and after the intervention. Method of measurement: By ELISA or enzymatic laboratory method. Creatinine. Timepoint: 24–48 hours before and after the intervention. Method of measurement: By ELISA or enzymatic laboratory method. Estimated Glomerular Filtration Rate. Timepoint: 24–48 hours before and after the intervention. Method of measurement: By ELISA or enzymatic laboratory method. Systolic blood pressure. Timepoint: 24–48 hours before and after the intervention. Method of measurement: Using a German Beurer device. Diastolic blood pressure. Timepoint: 24–48 hours before and after the intervention. Method of measurement: Using a German Beurer device. Resting heart rate. Timepoint: 24–48 hours before and after the intervention. Method of measurement: Using a German Beurer device. Mean arterial pressure. Timepoint: 24–48 hours before and after the intervention. Method of measurement: Using the formula. Body Mass Index. Timepoint: 24–48 hours before and after the intervention. Method of measurement: Using the formula. Waist-to-hip circumference ratio. Timepoint: 24–48 hours before and after the intervention. Method of measurement: Using the formula. Waist-to-height ratio. Timepoint: 24–48 hours before and after the intervention. Method of measurement: Using the formula. Body weight. Timepoint: 24–48 hours before and after the intervention. Method of measurement: Scale. Height. Timepoint: 24–48 hours before the intervention. Method of measurement: Wall-mounted height measure. Wall squat test. Timepoint: 24–48 hours before the intervention. Method of measurement: By recording the duration. 30-Second Chair Stand Test. Timepoint: 24–48 hours before the intervention. Method of measurement: By counting the repetitions. Quality of Life. Timepoint: 24–48 hours before the intervention. Method of measurement: Questionnaire. Iran National Science Foundation Approved 2026-05-26 Research Ethics Committees of Kharazmi University Kharazmi University, Shahid Keshvari Stadium, Shahid Hesari Street, Madar Square Tehran Tehran Iran (Islamic Republic of)