IRCT20260702070046N1 IRCT 2026-07-08 Shiraz University of Medical Sciences The effect of topical timolol on wound healing after fingertip amputation. The Effect of Topical Timolol on Wound Healing Following Fingertip Amputation: A Randomized Clinical Trial 2026-07-23 anticipated 88 Recruiting https://irct.ir/trial/91411 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Enrolled patients were randomised 1:1 to the timolol or control arm using a computer generated randomisation sequence in permuted blocks of four and six, Blinding description: This study was single-blind. Outcome assessors (clinicians performing wound inspection and two-point discrimination testing) were blinded to treatment allocation. However, patient blinding was not feasible due to the visible difference in the application method between topical timolol drops and normal saline drops. 2-3 Fingertip amputation (traumatic). Intervention 1: Intervention group: Timolol maleate ophthalmic solution 0.5%, two drops (approximately 50 μl per drop) were applied to the wound surface once daily. After application of the drops, the wound was covered with sterile Vaseline gauze. Patients or caregivers received complete instructions on how to apply the drops and change the dressing. Intervention 2: Control group: Standard wound care included two drops of normal saline on the wound and then a Vaseline gauze dressing with a non-adhesive layer similar to the intervention group. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is Due to the single-center nature of the study, limited resources, and concerns regarding patient privacy and data confidentiality, there is no plan to share individual participant data (IPD) publicly.