Comparative clinical trial of induction of anesthesia with midazolam and Sodium Thiopental versus Thiopental alone in patients which are candidates for Electroconvulsive therapy

The aim of this clinical trial is comparison of induction of anesthesia with midazolam and Sodium Thiopental and Sodium Thiopental alone, in patients selected for Electroconvulsive therapy (ECT). Inclusion criteria: patients with major depression; age over 18 year. Exclusion criteria: air way obstruction; obesity; somnolence; kidney and hepatic failure; muscle weakness; severe asthma; all ECT contraindications; patient's discontent. This is a clinical trial on 60 subjects who are selected for this study by agreement of a psychiatric. History taking and necessary examinations are done the night before ECT. These subjects are divided into two groups of 30 ones (15 male and 15 female). At the time of entrance to ECT room, their vital signs are measured and documented. In group A, Sodium Thiopental (3 mg/Kg) is injected for induction and in group B, Sodium Thiopental (1.5 mg/Kg) and midazolam (2.5 mg) are administered. In both groups Succinylcholine (0.5 mg/kg) is used for relaxation. After induction of anesthesia, standard dose of electroshock is given by psychiatric, and starting and ending point of convulsion is measured by chronometer. The subject is referred to recovery room following returning of breathing and securing vital signs, and remained until orientation recovery. Duration of anesthesia and recovery period are measured and documented.

Vice Chancellor of research; Kerman University of Medical Sciences