This study aimed to compare the effects of muscle energy technique with low-level laser on reducing neck and shoulder pain and disability in patients with myofascial trigger points in upper trapezius and levator scapula.This double- blind randomized controlled trial was performed in Zahedan University of Medical Sciences, in 2009. Thirty patients with trigger points in upper trapezius and levator scapula were participated through simple non probability sampling. Patients were randomly assigned to one of three groups, 10 in each group: including muscle energy technique, low-level laser, and placebo groups. In laser group, a low-level Ga-As laser was applied with 5 KHz frequency, a 100 mW point probe (average power), wavelength 905 nm, pulse duration 200 ns, 6 J/cm2 dosages per minute, for 3 minutes duration. In muscle energy group, we used stretching after post_ isometric relaxation. Placebo group treated using low-level laser without output. A 10 session treatment program, during two weeks, five sessions per week was performed for all groups. Before and after intervention, we assessed neck disability with Neck Disability Index, neck pain with Visual Analogue Scale and shoulder pain and disability with Shoulder Pain and Disability Index and cervical ranges of motion with specific neck goniometer.