Aim: A comparison of two different concentrations of NaOCl on pain following single-visit root canal treatment.
Methods: This study will be performed as a randomized triple-blinded clinical trial on 100 patients. The patients will be randomly allocated in two groups of 50 each and their root canals will be irrigated with either 5.25 or 2.5% of sodium hypochlorite.
Inclusion criteria:No systemic disease, first and second mandibular molar with irreversible pulpitis, normal preapical radiography, mild sensitivity to percussion, no or mild pretreatment pain, having no medication at least 6 hours before the treatment visit, at least 18 years, no allergic reaction to the lidocaine with epinephrine 1:80000, gelofen, and sodium hypochlorite. Exclusion criteria: Pregnancy and lactation, severe periodontal diseases, over instrumentation or overfilling, teeth that cannot be isolated, root canal calcification, root resorption, and the teeth that cannot be restored.
Root canals will be prepared in crown-down manner and RaCe rotary instruments.
At the same visit the root canals will be obturated with cold lateral condensation technique using gutta-percha and AH26 root canal sealer. At the end of treatment visit, each patient will receive one cap of Gelofen (400 mg). The patients will be given two forms. A visual analogue scale form that records the they rate the severity of their pain during 7 days period following the treatment. The other form is pertaining to analgesic consumption. Statistical analysis will be performed by someone else using who will be unaware of the intervention.