Objectives: The purpose of this study is investigating the effect of sesamin supplementation on some lipid profile, glycemic indices and serum levels of inflammatory markers, malondialdehyde and adiponectin in type 2 diabetic patients.
Design: 44 patients with type 2 diabetes from both of sex and aged between 30-60 years old are randomly assigned to two intervention and control groups.
Setting and conduct : The subjects in the intervention and control groups will receive 200 mg sesamin and 200 mg starch capsule daily for 8 weeks, respectively.
Participants including major eligibility criteria: Main inclusion criteria: having type 2 diabetes; 30 to 60 years old; BMI<30; Not having severe cardiovascular, hepatic, kidney, gastrointestinal, thyroid or inflammatory diseases; Not using insulin or taking corticosteroids, NSAIDS, immunosuppressives, multivitamin-mineral, fiber and omega 3 supplements since 3 weeks prior to the study and during intervention period; No smoking or addiction; No pregnancy or lactation; Not having any weight loose or weight gain regimes; No use of antibiotics. Main exclusion criteria: drug type and dose fluctuation during intervention period; unwilling to continue the study; looking sensitivity or allergy.
Intervention: The subjects in the intervention and control groups will receive 200 mg sesamin and 200 mg starch capsule daily for 8 weeks, respectively. Subjects will
ask not to change their diet, medications and physical activity routine throughout the trial.
main outcome measures (variables): serum levels of glucose, IL-6, TNF-α, hs-CRP, HbA1c, lipid profile, adiponectin and malondialdehyde are evaluated at the beginning and end of the intervention.