Comparison the effect of Berberis vulgaris (in metronidazole base), Myrtus communis (in metronidazole base), and metronidazole vaginal gel alone in treatment of women with bacterial vaginosis

The aim of this study was comparison the effect of Berberis vulgaris 5% in metronidazole base, Myrtus communis 2% in metronidazole base, and metronidazole 0.75% vaginal gel alone in treatment of women with bacterial vaginosis. This study was a clinical trial, double blind, single center, with random allocation. Physician and patients were unaware about the medication type. The patients were allocated randomly in the study groups according to encoded sheets. The population of study was the eligible women who referred to gynecology clinic of Hajar Hospital in Shahrekord. Inclusion criteria was diagnosis of bacterial vaginosis. The patients with sensitivity to Berberis vulgaris or Myrtus communis and treatment with systemic or topical antibiotic in the last two weeks were excluded. One hundred and twenty patients were randomly allocated in vaginal gel of Berberis vulgaris in metronidazole base, Myrtus communis in metronidazole base, or metronidazole alone groups(40 in each group). The intervention was conducted for 5 nights, with Berberis vulgaris 5% in metronidazole base, Myrtus communis 2% in metronidazole base or metronidazole vaginal gel alone. According to Amsel’s criteria, the efficacy of treatment was evaluated one week later. Absence or presence of one of the Amsel’s criteria was considered as primary outcome of the study. Moreover, the relapse was evaluated 3 weeks after treatment.

Shahrekord Medical University of Sciences