The aim of this study was assessing effect of twelve weeks combined exercise (aerobic-resistance) on plasma levels of Myostatin in obese youth. This study is a semi-experimental one. Thirty obese adolescents are willing to cooperate voluntarily; they will be randomly divided in two groups: experimental group and control group. Then, the experimental group will receive combined exercise program (aerobic training consisted of running on a treadmill for 20 minutes at 60-70% of maximal oxygen consumption and (intensity resistance training 70% of one repetition maximum (1RM) for 2 sets of 10 repetitions per movement) for 12 weeks (three sessions per week). The control group will receive no intervention but will follow. Variables including weight, body fat percentage, BMI, VO2max will measured in both groups before and after exercises. Blood samples will be collected in two stages, 48 hours before and after exercise to measure of plasma level of Myostatin.
General information
Acronym
IRCT registration information
IRCT registration number:IRCT2016032926251N2
Registration date:2016-04-16, 1395/01/28
Registration timing:registered_while_recruiting
Last update:
Update count:0
Registration date
2016-04-16, 1395/01/28
Registrant information
Name
Iman Zakavi
Name of organization / entity
Abadan Medical Sciences School
Country
Iran (Islamic Republic of)
Phone
+98 916 814 3051
Email address
zakavi.i@ajums.ac.ir
Recruitment status
Recruitment complete
Funding source
Abadan Medical Sciences School, Vice chancellor for research
Expected recruitment start date
2016-02-20, 1394/12/01
Expected recruitment end date
2016-04-20, 1395/02/01
Actual recruitment start date
empty
Actual recruitment end date
empty
Trial completion date
empty
Scientific title
The effect of twelve weeks combined exercise (aerobic- resistance) on plasma levels of Myostatin obese adolescents
Public title
The effect of combined exercise on Myostatin obese adolescents
Purpose
Treatment
Inclusion/Exclusion criteria
Inclusion criteria: all male students in middle and high schools in Baghmalek city; BMI higher than 30; lack of any disease؛ non smokiners and drugs users; parental consent and sign a written consent.
Exclusion criteria: the absence of more than three days in training; subjects who had a history of the sport and disease as well as subjects who use a weight loss method.
Age
From 12 years old to 16 years old
Gender
Male
Phase
N/A
Groups that have been masked
No information
Sample size
Target sample size:
30
Randomization (investigator's opinion)
Randomized
Randomization description
Blinding (investigator's opinion)
Not blinded
Blinding description
Placebo
Not used
Assignment
Parallel
Other design features
After determining the obesity of the subjects, 30 people will be selected randomly and randomly divided into two groups: control (n = 15 ) and experimental (n = 15 ) will be divided.
Secondary Ids
empty
Ethics committees
1
Ethics committee
Name of ethics committee
Ethics committee of Abadan Medical Sciences School
Street address
Ethics committee of Abadan Medical Sciences School, Vice chancellor for research, Opposite International Airport Jami Abadan, Flying field, Abadan City , Khouzestan.
City
Abadan
Postal code
517
Approval date
2015-12-22, 1394/10/01
Ethics committee reference number
IR.ABADANUMS.REC.1394.48
Health conditions studied
1
Description of health condition studied
Obesity
ICD-10 code
E66
ICD-10 code description
Obesity
Primary outcomes
1
Description
vo2max
Timepoint
Before intervention, 3 months after intervention
Method of measurement
ml/kg/min---By ROCKPORT 1-mile walk test
2
Description
Myostatin
Timepoint
Before intervention, 3 months after intervention
Method of measurement
ng/l-using human Myostatin and ELISA kits
Secondary outcomes
1
Description
Weight
Timepoint
Before intervention, 3 months after intervention
Method of measurement
kg, In body Device
2
Description
BMI
Timepoint
Before intervention, 3 months after intervention
Method of measurement
kg, In body Device
3
Description
fat percentage
Timepoint
Before intervention, 3 months after intervention
Method of measurement
kg, In body Device
Intervention groups
1
Description
"Intervention group: the experimental group will receive combined exercise program (aerobic training consisted of running on a treadmill for 20 minutes at 60-70% of maximal oxygen consumption (VO2max) and (intensity resistance training 70% of one repetition maximum (1RM) for 2 sets of 10 repetitions per movement) for 12 weeks (three sessions per week) "
Category
Other
2
Description
"control group: participate in daily activities"
Category
Other
Recruitment centers
1
Recruitment center
Name of recruitment center
Shahid Tabatabai Hospital
Full name of responsible person
Amin Delavari
Street address
Shahid Tabatabai Hospita, Street Ghale Kamisi, Baghmalek City, Kouzestan
City
Baghmalek
2
Recruitment center
Name of recruitment center
Abadan Medical Sciences School Vice chancellor for research,
Full name of responsible person
Dr. Mohamad Mahboobi
Street address
Vice chancellor for research, Abadan Medical Sciences School, Opposite International Airport Jami Abadan, Flying field, Abadan City, Khouzestan.
City
Abadan
Sponsors / Funding sources
1
Sponsor
Name of organization / entity
Vice Chancellor for research of Abadan Medical Sciences School
Full name of responsible person
Dr. Mohamad Mahboobi
Street address
Abadan Medical Sciences School, Opposite International Airport Jami Abadan, Flying field, Abadan City, Khouzestan.
City
Abadan
Grant name
Grant code / Reference number
Is the source of funding the same sponsor organization/entity?
Yes
Title of funding source
Vice Chancellor for research of Abadan Medical Sciences School
Proportion provided by this source
100
Public or private sector
empty
Domestic or foreign origin
empty
Category of foreign source of funding
empty
Country of origin
Type of organization providing the funding
empty
Person responsible for general inquiries
Contact
Name of organization / entity
Abadan Medical Sciences School
Full name of responsible person
Iman Zakavi
Position
MSc
Other areas of specialty/work
Street address
Abadan Medical Sciences School, Opposite International Airport Jami Abadan, Flying field, Abadan City, Khouzestan.
City
Abadan
Postal code
517
Phone
+98 61 5326 5358
Fax
Email
imanzakavi@yahoo.com; zakavi.i@ajums.ac.ir
Web page address
Person responsible for scientific inquiries
Contact
Name of organization / entity
Abadan Medical Sciences School
Full name of responsible person
Iman Zakavi
Position
MSc
Other areas of specialty/work
Street address
AbadVice chancellor for research, Abadan Medical Sciences School, Opposite International Airport Jami Abadan, Flying field, Abadan City, Khouzestan.
City
Abadan
Postal code
517
Phone
+98 51 5326 5358
Fax
Email
imanzakavi@yahoo.com; zakavi.i@ajums.ac.ir
Web page address
Person responsible for updating data
Contact
Name of organization / entity
Abadan Medical Sciences School
Full name of responsible person
Iman Zakavi
Position
MSc
Other areas of specialty/work
Street address
Abadan Medical Sciences School, Opposite International Airport Jami Abadan, Flying field, Abadan City, Khouzestan.
City
Abadan
Postal code
Phone
+98 61 5326 5361
Fax
Email
imanzakavi@yahoo.com; zakavi.i@ajums.ac.ir
Web page address
Sharing plan
Deidentified Individual Participant Data Set (IPD)