The effect of topical herbal formulation containing of aloe vera gel,licorice, pomegranate and zataria extract on mild to moderate acne

The aim of this study is to determine the Effectiveness of Licorice, Pomegranate, Aloe vera and Zataria topical formulation on reducing mild to moderate acne symptoms.

Two arm parallel double blinded randomised clinical trial phase 2-3 with 2 groups; Control group and Intervention group.

All patients referred to Alzahra hospital of Isfahan, Iran, who have inclusion criteria were assigned randomly in one of the treatment methods for 8 weeks. These patients randomly receive a package containing a herbal formulation or clindamycin .Unique codes, which is generated by the software, will be used on the drug boxes. During the research, the randomization list is held by the statistic consultant, and the participants, the project implementer and all those who participate in the measurement of the indicators will not be aware of the assigned groups.then response of treatment will be evaluated at week 4, 8, 12.

Inclusion criteria: patients with mild to moderate acne, defined as global acne grading system (GAGS) scale,patients who have not used topical anti acne drugs in the recent month,patients who have not used oral anti acne drugs in past 2 months Exclusion criteria:pregnancy,had a skin disease,were known to be allergic or sensitive to any of the study medications,lactating.

"Control group": Patients who receive topical Gel of clindamycin 1% Najo after washing with antibacterial soap 3times in day for two months "Intervention group": Patients who receive topical herbal formulation made in ahvaz pharmacy school containing extract of Licorice , Pomegranate, Zataria and Aloe vera gel after washing with antibacterial soap 3 times in day for two months

Total lesion count and acne severity index

For randomization, the permuted block randomization will be used with quadruple blocks. blocks will be produced by using the online site (www.sealedenvelope.com)

Unique codes, which is generated by the software, will be used on the drug boxes. By entering each individual into the study based on the produced sequence, the drug box in which the code is registered, will be assigned to the individual. During the research, the randomization list is held by the statistic consultant, and the participants, the project implementer and all those who participate in the measurement of the indicators will not be aware of the assigned groups

Only a part of the data will be shared

The access period will be 6 months after the publication of the results

Six months after the publication of this study papers, the obtained data will be available to the applicant researchers for further analysis

Six months after the publication of this study papers, the obtained data will be available to the applicant researchers for further analysis

Applicants can be contacted with corresponding author by e-mail

Applicants will be able to access the obtained data from current study by sending an email to the corresponding author up to one month