Protocol summary

Study aim
Design and manufacturing of new “AFO” and evaluation of its effect on knee addaction moment and kinetic parameters of gait in people with knee OA
Design
Study design: Before- after design clinical trial. ُSample size: 28 subjects with medial compartment knee OA Study phases: Before wearing the orthosis and when wearing the orthosis
Settings and conduct
The current study will be carried out in faculty of rehabilitation science of Iran university of medical sciences and on the hospital outpatients who had prescribed by an orthopedic physician to use a knee orthosis.
Participants/Inclusion and exclusion criteria
Inclusion Criteria Medial compartment knee OA with grade 2 or 3 of KL scale Age range 35- 70 years old BMI range 18.5 - 35 Exclusion Criteria Lateral compartment knee OA Rheumatoid Arthritis Osteoarthritis of ankle or hip or vertebral column or patellofemoral joint Chronic or severe disturbances that lead to change in the gait pattern of the participants and can be recognized by the researchers observational assessment. History of operation in lower limb History of injection or operation in the last 6 months
Intervention groups
Intervention group: people with knee osteoarthritis after wearing "َAFO for Knee OA" orthosis. Control group: people with knee osteoarthritis before wearing "َAFO for Knee OA" orthosis.
Main outcome variables
Comport- Knee addaction moment- Kinetic parameters when walking

General information

Reason for update
Acronym
IRCT registration information
IRCT registration number: IRCT20160904029684N3
Registration date: 2019-03-19, 1397/12/28
Registration timing: prospective

Last update: 2019-03-19, 1397/12/28
Update count: 0
Registration date
2019-03-19, 1397/12/28
Registrant information
Name
Kourosh Barati
Name of organization / entity
Iran University of Medical Sciences
Country
Iran (Islamic Republic of)
Phone
+98 935 882 7110
Email address
barati.k@tak.iums.ac.ir
Recruitment status
Recruitment complete
Funding source
Expected recruitment start date
2019-04-03, 1398/01/14
Expected recruitment end date
2019-09-23, 1398/07/01
Actual recruitment start date
empty
Actual recruitment end date
empty
Trial completion date
empty
Scientific title
Design and manufacturing of new “ankle foot orthosis for knee osteoarthritis” and evaluation of its effect on knee addaction moment and gait kinetic parameters in people with knee osteoarthritis.
Public title
Design and manufacturing of "new orthosis for knee osteoarthritis" and evaluation of its effect on gait in people with knee osteoarthritis
Purpose
Treatment
Inclusion/Exclusion criteria
Inclusion criteria:
Medial compartment knee OA with grade 2 or 3 of KL scale Age range 35- 70 years old BMI range 18.5 - 35
Exclusion criteria:
Lateral compartment knee OA Rheumatoid Arthritis Osteoarthritis of ankle or hip or vertebral column or patellofemoral joint Chronic or severe disturbances that lead to change in the gait pattern of the participants and can be recognized by the researchers observational assessment. History of operation in lower limb History of injection or operation in the last 6 months
Age
From 35 years old to 70 years old
Gender
Both
Phase
2
Groups that have been masked
No information
Sample size
Target sample size: 28
Randomization (investigator's opinion)
N/A
Randomization description
Blinding (investigator's opinion)
Not blinded
Blinding description
Placebo
Not used
Assignment
Single
Other design features

Secondary Ids

empty

Ethics committees

1

Ethics committee
Name of ethics committee
Ethical committee of Iran University of Medical Science
Street address
Shahnazari st.- Mirdamad Blvd.- Tehran
City
tehran
Province
Tehran
Postal code
۱۳۴۸۷ - ۱۵۴۵۹
Approval date
2019-02-24, 1397/12/05
Ethics committee reference number
IR.IUMS.REC.1397.1120

Health conditions studied

1

Description of health condition studied
Knee Osteoarthritis
ICD-10 code
M17.10
ICD-10 code description
Unilateral primary osteoarthritis, unspecified knee

Primary outcomes

1

Description
Knee adduction moment
Timepoint
Before wearing orthosis and after wearing orthosis
Method of measurement
Force plate synchronized with the motion analysis instrument

2

Description
Comfort
Timepoint
Before wearing orthosis and after wearing orthosis
Method of measurement
questionnaire

3

Description
Kinetic parameters
Timepoint
Before wearing orthosis and after wearing orthosis
Method of measurement
Force Plate

Secondary outcomes

empty

Intervention groups

1

Description
Intervention group: Participants with knee OA will perform the biomechanical test in three conditions: when wearing no orthosis, when wearing "AFO for Knee OA" Orthosis with un-lucked supination/pronation joint and when wearing "AFO for Knee OA" Orthosis with lucked supination/pronation joint.
Category
Rehabilitation

Recruitment centers

1

Recruitment center
Name of recruitment center
Firouzgar Hospital
Full name of responsible person
Kourosh Barati
Street address
Firouzgar Hospital, Firouzeh St., Valiasr St., Valiasr Sq,.
City
Tehran
Province
Tehran
Postal code
۱۵۹۳۷۴۷۸۱۱
Phone
+98 21 8214 1600
Email
h_firoozgar@yahoo.com

Sponsors / Funding sources

1

Sponsor
Name of organization / entity
Iran University of Medical Sciences
Full name of responsible person
Dr Kouhpayeh
Street address
Iran University of Medical Sciences, Shahid Hemmat Highway, Tehran
City
Tehran
Province
Tehran
Postal code
۱۴۴۹۶۱۴۵۳۵
Phone
+98 21 86701
Email
adminsite@iums.ac.ir
Grant name
Grant code / Reference number
Is the source of funding the same sponsor organization/entity?
Yes
Title of funding source
Iran University of Medical Sciences
Proportion provided by this source
100
Public or private sector
Public
Domestic or foreign origin
Domestic
Category of foreign source of funding
empty
Country of origin
Type of organization providing the funding
Academic

Person responsible for general inquiries

Contact
Name of organization / entity
Iran University of Medical Sciences
Full name of responsible person
Koorosh Barati
Position
PhD candidate
Latest degree
Master
Other areas of specialty/work
Prostheses & Orthoses
Street address
Department of Orthosis & prosthesis, School of rehabilitation Sciences, Shahnazari St, Madar Sq, Mirdamad Ave, Tehran, Iran
City
Tehran
Province
Tehran
Postal code
۱۴۴۹۶۱۴۵۳۵
Phone
+98 21 8670 2555
Fax
Email
barati.k@tak.iums.ac.ir
Web page address

Person responsible for scientific inquiries

Contact
Name of organization / entity
Iran University of Medical Sciences
Full name of responsible person
Koorosh Barati
Position
PhD candidate
Latest degree
Master
Other areas of specialty/work
Prostheses & Orthoses
Street address
Department of Orthosis & prosthesis, School of rehabilitation Sciences, Shahnazari St, Madar Sq, Mirdamad Ave, Tehran, Iran
City
Tehran
Province
Tehran
Postal code
۱۴۴۹۶۱۴۵۳۵
Phone
+98 21 8670 2555
Fax
Email
barati.k@tak.iums.ac.ir
Web page address

Person responsible for updating data

Contact
Name of organization / entity
Iran University of Medical Sciences
Full name of responsible person
Koorosh Barati
Position
PhD candidate
Latest degree
Master
Other areas of specialty/work
Prostheses & Orthoses
Street address
Department of Orthosis & prosthesis, School of rehabilitation Sciences, Shahnazari St, Madar Sq, Mirdamad Ave, Tehran, Iran
City
Tehran
Province
Tehran
Postal code
۱۴۴۹۶۱۴۵۳۵
Phone
+98 21 8670 2555
Fax
Email
barati.k@tak.iums.ac.ir
Web page address

Sharing plan

Deidentified Individual Participant Data Set (IPD)
Yes - There is a plan to make this available
Study Protocol
Yes - There is a plan to make this available
Statistical Analysis Plan
Yes - There is a plan to make this available
Informed Consent Form
Yes - There is a plan to make this available
Clinical Study Report
Yes - There is a plan to make this available
Analytic Code
Yes - There is a plan to make this available
Data Dictionary
Yes - There is a plan to make this available
Title and more details about the data/document
After ensuring that the participants are not identifiable, all potential data could be shared
When the data will become available and for how long
6 month after article publication
To whom data/document is available
Researchers that are working in IUMS
Under which criteria data/document could be used
In condition in which the priority of research innovation is not threatened
From where data/document is obtainable
Sending the request to the corresponding author via email.
What processes are involved for a request to access data/document
The request is reviewed by the corresponding author and the decision will be made within 2 weeks of after receiving the request.
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