Comparison between magnesium sulfate and paracetamol in Analgesic effect and venous blood gas alterations during Intravenous Regional Anesthesia with Lidocaine

This study will be performed by the aim of comparison the analgesia and venous blood gas alterations by adding Paracetamol or Magnesium Sulphate to Lidocaine in upper extremity surgeries under intravenous regional anesthesia as a double blinded clinical trial with placebo. Ninety ASA class I, II patients between 15 to 65 years divided into 3 groups of 30 cases. Allergic reaction to Lidocaine, Acetaminophen or Magnesium sulphate is the main exclusion criterion. Group 1(control) will receive 3 mg/kg Lidocaine 0.5% plus Saline IV by the volume of 40 ml. Group 2(Magnesium Sulphate) will get 3 mg/kg Lidocaine 0.5% plus 10 ml Magnesium Sulphate 15% and Saline IV by the volume of 40 ml. Group 3(Paracetamol) will have 3 mg/kg Lidocaine 0.5% plus 300 mg Paracetamol and Saline IV by the volume of 40 ml. Sensory block evaluation will be done by pinprick and motor block by inability to move the extremity which will be assessed every 30 seconds. Visual Analog scale is used for measure pain sensation. If tourniquet pain produces VAS =4 or more, 1 mic/kg Fentanyl will be injected. Venous PH, PO2 and PCO2 at the beginning and before deflation of tourniquet will be measured. At the first time after operation by VAS=4, 2 mg of Morphine IV will be given every 15 minutes to decrease the score to 3 or less. Total dose of Morphine and VAS, BP, HR and SPO2 will be assessed during 24 hour

Shahid Beheshti University of Medical Sciences