Comparison of Effect of Magnesium Sulfate and ondansetron in Prevention of Shivering in Patients during Spinal Anesthesia

Comparison of Effect of Magnesium Sulfate and ondansetron in Prevention of Shivering in Patients during Spinal Anesthesia

The clinical trial has a control group, with parallel groups, a blind, randomized, Phase 2 on 80 patients. To randomize the 80 cards in two different colors, 40 red cards and 40 blue cards were poured into the Ondansetron group and magnesium sulfate inside the bag and were accidentally drawn up by the anesthesia technician, for each patient, a card was pulled

Pregnant women with American Society of Anesthesia class I under cesarean section with spinal procedure were studied in Amirolomenin Hospital of Semnan and randomly compared to Ondansetron and sulfat Magnesium Effect for shivering prevention

conditions for entering the study pregnant women with American Society of Anesthesia class I who have a cesarean section with spinal anesthesia conditions for not entering the study pregnant women with American Society of Anesthesia class II , III , IV Fever ( Central body temperature over 38 Celsius) or hypothermia ( Central body temperatureless than 36.5 Celsius) contraindications of spinal anesthesia (Patient dissatisfaction, lack of patient cooperation, increased intracranial pressure) allergy to the drugs studied recieving blood during surgery History of petidine and magnesium intake before surgery

In the first intervention group،30 Milligrams per kilogram diluted magnesium sulfate with 500 cc of normal saline is infused over 30 minutes by the pump syringe. The maximum dose of magnesium was 4 gram.In the second intervention group ondansetron is infused at 0.1 Milligrams per kilogram with 500 cc of normal saline for 30 minutes.

shivering, temperature, age, group therapy, blood pressure, heart rate, arterial oxygen saturation, nausea and vomiting.

To randomize the study, 80 cards in two different colors, 40 red cards and 40 Blue cards was poured into a bag for the Ondansteron and Magnesium Sulfate groups, respectively, and was randomly drawn by an anesthesia technician, and a card was drawn and discarded for each patien

Patients' Shivering were measured every 15 to 90 minutes by a person other than the researcher who did not know the study group and were recorded in a special form. Due to the nature of the intervention and the design of the study, only the researcher is aware of the injection. Patients will be unaware that they belong to the intervention or control group. Also, the statistician is not aware of the patients' identities and only collects information through a numerical list that does not have the names of the patients. As a result, the study will be double-blind, and prevention will be achieved. due to differences in the treatment of patients. Also, syringes containing the drug and normal saline are identical in appearance

All potential data can be shared after publication of result

At the end of data collection period until the publication of results

Only doctors and medical students

Only when people intend to research about this topic

To the scientific and executive members of the project Email: babak.hoseinzadeh@semums.ac.ir elhamghanbari1824@yahoo.com

Communicate with the scientific and executive authorities of the project - Submiting their official letter from research centers -using the patient's information only at designated center - Submiting their final report obtained by information