Effect of antibiotic and application on septalmucosal outcome afterseptoplasty

Effect of antibiotic and splint aplicationon septal mucosal outcome after septoplasty

Clinical trial with control group, with parallel groups, one-way blind, randomized, on 90 patients. And the selection of non-random patients was at the discretion of the surgeon

the patient that needed septoplasty in Qaem and Emaam Reza hosp . the culture was got from nasal mucosa after surgery and two weeks later and see the efficacy of antibiotic on that and Unilateral blinding was based on the surgeon's discretion to implant the splint

All of the patient betwen 18 to 65 y old candidate for septoplasty didntn have nasal ans sinus surgical history and have no immunocompromised disease

A group no. 1 that didnt give them antibiotic after septoplasty and the second gtoup get antibiotic after septoplasty and third group that use splint in the surgery and give them antibiotic after that .

Amount and kind of mucosal microorganisms before and two weeks after septoplasty in three group

90 patients are considered as candidates for septoplasty due to septal deviation and nasal obstruction. During the operation, patients who need splints at the surgeon's discretion are considered as a study group and splints are used and after surgery. For this group of oral antibiotics, 500 mg cephalexin capsules are prescribed. Other patients for whom splints have not been used during surgery are assigned to two groups using a random number table. For one group of oral antibiotics, 500 mg of cephalexin capsules are prescribed, and for the control group, according to the opinion of a pharmacist, placebo is used instead of antibiotics. The placebo used is the cocci-ten di-vitamin capsule, which is similar to how antibiotics are used for patients in the treatment group. The placebo used was prepared in collaboration with the pharmaceutical group with a similar appearance to the antibiotic used, which has a complementary aspect and this drug does not have any therapeutic properties. Medications will be given as capsules to patients one hour before surgery .All study groups were generally introduced and explained to the patient , Thus, in case of a faulty injury, a splint needs to be implanted and due to the splint, antibiotics are prescribed, and in case of complete mucosal health and no need to implant a splint, patients in both groups should be prescribed antibiotics and no antibiotics should be prescribed to determine the need. To the drug, in cases where there is no need to implant a split in the healthy mucosa And while the patient agrees to be in one of the groups, with the discretion of the physician while obtaining the written and inserted informed consent, they enter the study . Therefore, due to the nature of the study, the physician in charge of surgery will be aware of the allocation of splints to patients, but patients will not be aware of the use of splints or the type of drug used.