The purpose of the present study is to determine the effect of an 8-week resistance training program on rotational levels of Klotho and myostatin of muscle function in middle-aged women.
Design
Practical trial with 20 subjects who entered in two groups of training and control using a random number table.
Settings and conduct
The subjects practiced three sessions per week for 8 weeks. The training protocol consisted of 8 stations of knee flexion, lying leg curl, bodyweight seated calf raise, barbell guillotine bench press, seated dumbbell shoulder press, barbell curl, LAT pull, and six-pack crunch performed by the subjects with the intensity of 50-80% of maximum strength.
Participants/Inclusion and exclusion criteria
Target age range, females, no history of regular physical activity, no cardiovascular disease, no neuromotor diseases, no high blood pressure, no diabetes
Intervention groups
Eight weeks of resistance training with bodybuilding equipment and control group without any exercise
Main outcome variables
Increasing the amount of Klotho, decreasing myostatin, and improving muscle function
General information
Reason for update
Acronym
IRCT registration information
IRCT registration number:IRCT20211016052781N1
Registration date:2021-12-03, 1400/09/12
Registration timing:retrospective
Last update:2021-12-03, 1400/09/12
Update count:0
Registration date
2021-12-03, 1400/09/12
Registrant information
Name
fatemeh foroughinasab
Name of organization / entity
The University of Shahid Chamran ahvaz
Country
Iran (Islamic Republic of)
Phone
+98 61 4252 3137
Email address
fafon1806@gmail.com
Recruitment status
Recruitment complete
Funding source
Expected recruitment start date
2021-07-23, 1400/05/01
Expected recruitment end date
2021-09-23, 1400/07/01
Actual recruitment start date
2021-07-23, 1400/05/01
Actual recruitment end date
2021-09-23, 1400/07/01
Trial completion date
2021-09-25, 1400/07/03
Scientific title
The eight weeks effect of resistance training on rotational levels of Klotho and myostatin of muscle function in middle-aged women
Public title
The eight weeks effect of resistance training on rotational levels of Klotho and myostatin of muscle function in middle-aged women
Purpose
Education/Guidance
Inclusion/Exclusion criteria
Inclusion criteria:
Target age range
Females
No history of regular physical activity
Exclusion criteria:
Having cardiovascular disease
high blood pressure
neuromotor diseases
Diabetes
48 hours before the first session and after the last session
Method of measurement
Using the ELISA kit
2
Description
Myostatin
Timepoint
48 hours before the first session and after the last session
Method of measurement
Using the ELISA kit
3
Description
Muscle function (Strength, endurance, muscle strength)
Timepoint
48 hours before the first session and after the last session
Method of measurement
Maximum power,30% of maximum power,Sargent test
Secondary outcomes
empty
Intervention groups
1
Description
Intervention group: Resistance training group: After returning to the training site, the subjects warmed up their bodies for 10 minutes, which included general and specific warm-ups. 8 stations of knee flexion, lying leg curl, body weight seated calf raise, barbell guillotine bench press, seated dumbbell shoulder press, barbell curl, LAT pull, and six-pack crunch was performed with the intensity of 50-80% of maximum power. The number of repetitions of each station was 8-12. The subjects rested for 60-90 seconds between stations. There was also 2-3 minutes of rest time between training sessions (an 8-station exercise). There were 3 training sessions and at the end of the training, the subjects cooled their bodies for 5 minutes with stretching movements. In order to observe the principle of overload, 5% was added to the training load every week until the fifth week, so the intensity of 50-55% to the eighth week reached the maximum of 75-80% since the first week.
Category
N/A
2
Description
Control group: They did not have any sports activities during the project
Category
N/A
Recruitment centers
1
Recruitment center
Name of recruitment center
Shahid Chamran University
Full name of responsible person
Fatemeh Foroughi Nasab
Street address
No. 228 Dehghan Street between Motahhari and Khayyam streets
City
dezful
Province
Khouzestan
Postal code
6461885666
Phone
+98 61 4252 3137
Email
fafon1806@gmail.com
Sponsors / Funding sources
1
Sponsor
Name of organization / entity
Shahid Chamran University
Full name of responsible person
Fatemeh Foroughi Nasab
Street address
No. 228 Dehghan Street between Motahhari and Khayyam streets
City
Dezful
Province
Khouzestan
Postal code
6461885666
Phone
+98 61 4252 3137
Email
fafon1806@gmail.com
Grant name
Grant code / Reference number
Is the source of funding the same sponsor organization/entity?
Yes
Title of funding source
Shahid Chamran University
Proportion provided by this source
100
Public or private sector
Public
Domestic or foreign origin
Domestic
Category of foreign source of funding
empty
Country of origin
Type of organization providing the funding
Academic
Person responsible for general inquiries
Contact
Name of organization / entity
Shahid Chamran University
Full name of responsible person
Fatemeh Foroughi Nasab
Position
Ph.D candidate
Latest degree
Ph.D.
Other areas of specialty/work
Sports physiology
Street address
No. 228 Dehghan Street between Motahhari and Khayyam streets
City
Dezful
Province
Khouzestan
Postal code
6142523137
Phone
+98 61 4252 3137
Email
fafon1806@gmail.com
Person responsible for scientific inquiries
Contact
Name of organization / entity
Shahid Chamran University
Full name of responsible person
Fatemeh Foroughi Nasab
Position
Ph.D candidate
Latest degree
Ph.D.
Other areas of specialty/work
Sports physiology
Street address
No. 228 Dehghan Street between Motahhari and Khayyam streets
City
Dezful
Province
Khouzestan
Postal code
6461885666
Phone
+98 61 4252 3137
Email
fafon1806@gmail.com
Person responsible for updating data
Contact
Name of organization / entity
Shahid Chamran University
Full name of responsible person
Fatemeh Foroughi Nasab
Position
Ph.D candidate
Latest degree
Ph.D.
Other areas of specialty/work
Sports physiology
Street address
No. 228 Dehghan Street between Motahhari and Khayyam streets
City
Dezful
Province
Khouzestan
Postal code
6461885666
Phone
+98 61 4252 3137
Email
fafon1806@gmail.com
Sharing plan
Deidentified Individual Participant Data Set (IPD)
Undecided - It is not yet known if there will be a plan to make this available
Study Protocol
Undecided - It is not yet known if there will be a plan to make this available
Statistical Analysis Plan
Not applicable
Informed Consent Form
Undecided - It is not yet known if there will be a plan to make this available