Comparison of fractional co2 laser therapy alone and with its combination with topical timolol or topical insulin in the treatment of acne scar, A randomized controlled clinical trial

Comparison of fractional co2 laser therapy alone and with its combination with topical timolol or topical insulin in the treatment of acne scar

A clinical trial with two treatment groups along with the control group (opposite side of the patient's face), with parallel groups, double-blind, randomized, phase 3 on 30 patients. Random Allocation Software is used for randomization.

This study is conducted on patients with acne scars who are referred to skin clinics of Shiraz University of Medical Sciences. Patients' lesions are randomly divided into two groups (right and left lesions). The plan is implemented in a double-blind manner.

Inclusion criteria: 1. The patients with moderate to severe atrophic acne scarring and no inflammatory lesions 2. Age above 15 years old. Exclusion criteria: 2. Pregnant and lactating patients 2. Patients who have inflammatory lesions patients who have active Koebner-inducing diseases such as psoriasis and Lichen planus 3. Patients who have Asthma, atrioventricular blocks, sinus bradycardia, diabetes mellitus 4. Prior use of beta blockers, 5. The patients who have received Isotretinoin in the past three months.

Group A lesions will receive fractional CO۲ laser therapy with distilled water on one side and the combination of fractional CO۲ laser therapy and topical Timolol Maleate ۰.۵% on the other side. Group B lesions will receive fractional CO۲ laser therapy with distilled water on one side and the combination of fractional CO۲ laser therapy and topical regular insulin on the other side. The mode of the fractional CO۲ device will be set to: Power: ۱۲, Stack:۲, Scanning dwell time: ۷۰۰, and Spacing: ۷۰۰. All of the patients will be asked to participate in three sessions of laser therapy at three-week intervals.

Acne Scar Assessment Scale (ASAS)

The randomization will follow a permuted block method, including 12 blocks of four, achieved by Random Allocation Software. In this regard, the lesions are divided into two groups A (right side of the face) and B (left side of the face). Dark-colored envelopes will be used to hide random allocation.

The used drugs will be poured into similar containers that will be tagged for A and B so that the resident and the patient will be ignorant of the applied medication. Only the secretary of the dermatology department will know the medication of each group.

Demographic data and the result of the clinical trial

One year later

Researchers

After the publication of the article based on the clinical trial, it will be possible to share the data. The recipients of the data can use the data by obtaining permission from the project managers. The managers of this project will allow the data to be used in secondary data analysis studies and systematic reviews.

Data requesters can submit their request by sending an email to each of the administrators that their names and emails have been entered into this system.

Data requesters can submit their request by sending an email to each of the administrators that their names and emails have been entered into this system.

Data requesters can submit their request by sending an email to each of the administrators that their names and emails have been entered into this system.