Comparison of the effectiveness of the combined treatment of topical minoxidil and topical cetirizine solution with topical minoxidil alone in male and female patient with moderate to severe androgenetic alopecia

Comparison of the effectiveness of the combined treatment of topical cetirizine solution and topical minoxidil with topical minoxidil alone in the treatment of androgenetic alopecia.

A clinical trial with a control group, with parallel groups, a blind strain, randomized, phase 3 on 62 patients, simple randomization using random number table method is used for randomization.

The number of 62 patients with androgenetic alopecia referring to the medical centers of Isfahan University of Medical Sciences from among the patients who are eligible to enter the study and have consented to participate in the study are randomly divided into two study groups. become First, a complete description of the patient's condition is taken and the patient is placed under photography in 4 standard views. Also, the number of hairs (non-vellus and vellus) on the surface of one square inch and the thickness of the hair are measured and recorded by dermatoscopy. Then the patients in two groups A and B are sent to the pharmacy. They are scheduled on a daily basis and the doctor is not aware of the type of group A and B, and they will be coded at the end of the study.4 months after the use of the topical medication, a re-examination with photography and dermatoscopy was performed, and the satisfaction score of the patients and the doctor was recorded.

People aged 18 to 50 years with androgenetic alopecia without other causes of alopecia and without serious underlying disease or recent systemic steroid use and without sensitivity to cetirizine and minoxidil

In the intervention group, patients receive minoxidil solution and cetirizine simultaneously, and in the comparison group, minoxidil solution is received alone.

Hair thickness, hair density, change of photography score, patient satisfaction

Randomization in the study is a simple random method, in this way, using a computer system, 31 numbers are randomly selected from 1 to 62 for one group (A), and 31 numbers for the other group (B). then based on the order of entry of the patients into the study and the number they get based on the order of entry, which is related to which list, they are entered into one of these two groups (A or B). The pharmacy is aware of whether the intervention group (cetirizine + minoxidil) or the comparison group (minoxidil alone) is A and B and is blinded to the doctor.

In order to blind the study, both cetirizine and minoxidil were given to the patients in the form of a solution and in the same packaging as numbers one and two, and the doctor did not know the type of medicine for each patient. (one-way blind method) The doctor secretly sent the patients with numbers A and B to the pharmacy, and only the pharmacist was aware of the type of treatment for these two groups, and at the end of the study and the end of the examinations, the type of treatment for each group will be revealed to the doctor. and B are each cetirizine and minoxidil or minoxidil alone)