Investigating the effect of topical dexamethasone at the site of thyroid surgery (on the parathyroids) on blood calcium levels after surgery, compared to the control group in patients who underwent total thyroidectomy.

Investigating the effect of topical dexamethasone in the thyroid surgery site (on the parathyroids) on blood calcium levels after surgery, compared to the control group in patients who underwent total thyroidectomy.

Clinical trial with control group, with parallel groups, randomized, phase 3 on 60 patients. A table of random numbers was used for randomization.

The current study is a randomized clinical trial with a before and after design. The statistical population under investigation is all total thyroidectomy candidate patients referred to Imam Khomeini Hospital in 1401, who will be divided into two groups of 30 people using a random number table after determining the inclusion and exclusion criteria. In the case group, after thyroidectomy in the same operating room, an ampoule of dexamethasone (8 mg-2 ml) will be sprayed at the thyroidectomy site, and no special action will be taken in the control group. The investigated times will be before thyroidectomy, 6 hours, 24 hours and 48 hours after thyroidectomy. The data collection tool is a questionnaire, and the data will be entered into SPSS version 22 software after collection.

Inclusion: patients with confirmed thyroid cancer, do not take calcium containing drugs and any corticosteroid drugs, have no history of thyroid or parathyroid surgery. Exclusion: Patients who needed re-operation before 48 hours due to surgical complications such as hematoma at the operation site.

In the case group, after thyroidectomy in the same operating room, an ampoule of dexamethasone (8 mg-2 ml) will be sprayed at the thyroidectomy site, and no special action will be taken in the control group. The times examined in our study will be before thyroidectomy, 6 hours, 24 hours and 48 hours after thyroidectomy.

Blood calcium level.

In this study, the sample size is 60 people, which is less than 100. If people are divided between 2 groups by simple random method. According to the rule of randomization of taps and lines, the number of taps and lines may not be equal in two groups. Therefore, the Block-Randomization method is used. The sample size calculated in this study is 30 people in each group. Therefore, 10 blocks of 4 people are formed and 5 blocks are randomly assigned to each group. As a result, the balance between the two groups is allocated in the form of 30 people to one group and another 30 people to the second group. A simple random method is used to assign people to each block. It means that people are placed in one of these blocks based on a table of random numbers