Comparison of the effect of local marcaine (port location) with intraperitoneal marcaine on painafter laparoscopic cholecystectomy

Comparison of the effect of local marcaine (site of ports) with intraperitoneal marcaine on pain after laparoscopic cholecystectomy surgery.

Clinical trial without control group, with parallel groups, one-sided blind, randomized, phase 2-3 on 28 patients, rand function of Excel software was used for randomization.

Patients in Aria Hospital of Mashhad will be randomly divided into two groups with the help of sealed envelopes: Group 1: Local infiltration (port site) of 20 ml of 0.25% bupivacaine solution at the end of the procedure before closing the wound, which will be 5 ml per port. Group 2: After removing the gallbladder, they will receive intraperitoneal infiltration of 20 ml of 0.25% bupivacaine solution in the bed of the gallbladder and under the right dome of the diaphragm.

Inclusion criteria : 1- Patients undergoing elective laparoscopic head cystectomy surgery 2- Age between 18 and 65 years Exclusion criteria: 1- The occurrence of unwanted complications during the operation 2- People with contraindications to the prescription of anesthetic drugs or opioids (patients with known hypersensitivity to the compounds of various anesthetic drugs)

Group 1: Local infiltration (port site) of 20 ml of 0.25% bupivacaine solution at the end of the procedure before closing the wound, which will be 5 ml per port. Group 2: After removing the gallbladder, they will receive intraperitoneal infiltration of 20 ml of 0.25% bupivacaine solution in the bed of the gallbladder and under the right dome of the diaphragm.

1- Postoperative pain is different in the two study groups. 2- The amount of additional pain relief after the operation is different in the two study groups.

Patients will be randomly divided into two groups with the help of sealed envelopes Group 1: Local infiltration (port site) of 20 ml of 0.25% bupivacaine solution at the end of the procedure before closing the wound, which will be 5 ml per port. Group 2: After removing the gallbladder, they will receive intraperitoneal infiltration of 20 ml of 0.25% bupivacaine solution in the bed of the gallbladder and under the right dome of the diaphragm.

This study will be conducted in the form of a two-group, single-blind clinical trial, where the patients will be unaware of the assigned treatment, on patients undergoing elective laparoscopic cephalocystectomy surgery at Aria Hospital in Mashhad. People with entry criteria and those without exit criteria will enter the study after providing an explanation about the design and completing the informed consent form. Patients will be randomly divided into two groups with the help of sealed envelopes Group 1: Local infiltration (port site) of 20 ml of 0.25% bupivacaine solution at the end of the procedure before closing the wound, which will be 5 ml per port. Group 2: After removing the gallbladder, they will receive intraperitoneal infiltration of 20 ml of 0.25% bupivacaine solution in the bed of the gallbladder and under the right dome of the diaphragm.