Protocol summary

Study aim
To compare the effects of Hand Arm Bimanual Intensive Training and Proprioception Neuromuscular Facilitation patterns on upper extremity dysfunction in patients with subacute strokes.
Design
Randomized Clinical Trial, single blind
Settings and conduct
Allied Hospital Faisalabad, Aziz Fatima Hospital Faisalabad and District Head Quarter Hospital Faisalabad.
Participants/Inclusion and exclusion criteria
Inclusion criteria includes Stroke patient clinically diagnosed or with scan of CT computed tomography or MRI magnetic resonance imaging, Sub-acute stroke patients, Age 35–60 years, Patient with GCS score >8 and vitally stable, On Mini-Mental State Exam score must be >24 and having no severe cognitive problems and Patients suffered from first time stroke and able to give informed consent. Exclusion criteria includes Patients with severe cardiopulmonary complications, Any intracranial implant, Patient with pacemaker, Any kind of cranial defect, Patients with worsening condition that causes difficulties for physiotherapy treatment, All the medical conditions except stroke that limited the use of upper limb, Patients with epilepsy and Patients having previous history of stroke on same side that diminish upper extremity function.
Intervention groups
Group A will receive Hand Arm Bimanual Intensive Training (HABIT) and Group B will receive Proprioceptive Neuromuscular Facilitation (PNF) patterns
Main outcome variables
Spasticity, Motor function of upper extremity, Activities of Daily Living.

General information

Reason for update
Acronym
HABIT & PNF
IRCT registration information
IRCT registration number: IRCT20230526058301N1
Registration date: 2023-09-11, 1402/06/20
Registration timing: registered_while_recruiting

Last update: 2023-09-11, 1402/06/20
Update count: 0
Registration date
2023-09-11, 1402/06/20
Registrant information
Name
Ayesha Affi
Name of organization / entity
The University of Faisalabad
Country
Pakistan
Phone
+92 41 8868326
Email address
2021-ms-pt-066@tuf.edu.pk
Recruitment status
Recruitment complete
Funding source
Expected recruitment start date
2023-07-24, 1402/05/02
Expected recruitment end date
2023-09-30, 1402/07/08
Actual recruitment start date
empty
Actual recruitment end date
empty
Trial completion date
empty
Scientific title
COMPARATIVE EFFECTS OF HAND ARM BIMANUAL INTENSIVE TRAINING (HABIT) AND PROPRIOCEPTIVE NEUROMUSCULAR FACILITATION (PNF) PATTERNS ON UPPER EXTREMITY DYSFUNCTION IN PATIENTS WITH SUBACUTE STROKE
Public title
COMPARATIVE EFFECTS OF HAND ARM BIMANUAL INTENSIVE TRAINING (HABIT) AND PROPRIOCEPTIVE NEUROMUSCULAR FACILITATION (PNF) PATTERNS ON UPPER EXTREMITY DYSFUNCTION IN PATIENTS WITH SUBACUTE STROKE
Purpose
Treatment
Inclusion/Exclusion criteria
Inclusion criteria:
Stroke patient clinically diagnosed or with scan of CT computed tomography or MRI magnetic resonance imaging Sub-acute stroke patients Age 35–60 years Patient with GCS score >8 and vitally stable On Mini-Mental State Exam score must be >24 and having no severe cognitive problems Patients suffered from first time stroke and able to give informed consent
Exclusion criteria:
Patients with severe cardiopulmonary complications Any intracranial implant Patient with pacemaker Any kind of cranial defect Patients with worsening condition that causes difficulties for physiotherapy treatment All the medical conditions except stroke that limited the use of upper limb Patients with epilepsy Patients having previous history of stroke on same side that diminish upper extremity function
Age
From 35 years old to 60 years old
Gender
Both
Phase
3
Groups that have been masked
  • Participant
Sample size
Target sample size: 46
Randomization (investigator's opinion)
Randomized
Randomization description
Randomization will be done by using Lottery method, in this method computerized generator will be used and patients will allocated into two groups according to numbers given to them.
Blinding (investigator's opinion)
Single blinded
Blinding description
Participants will be single blind in the study. He/ She kept blind about his/her own treatment group.
Placebo
Not used
Assignment
Parallel
Other design features

Secondary Ids

empty

Ethics committees

1

Ethics committee
Name of ethics committee
Ethics Committee of The University of Faisalabad
Street address
West Canal Road, Faisalabad
City
Faisalabad
Postal code
37610
Approval date
2023-03-24, 1402/01/04
Ethics committee reference number
TUF/DR/SA/MSPP/2023/242

Health conditions studied

1

Description of health condition studied
Stroke
ICD-10 code
169.4
ICD-10 code description
Subacute stroke

Primary outcomes

1

Description
Spasticity
Timepoint
At baseline, after second week of intervention, after fourth week of intervention, after sixth week of intervention and after eight week of intervention
Method of measurement
Modified Ashworth Scale

Secondary outcomes

1

Description
Motor Function of upper limb
Timepoint
At baseline, after second week of intervention, after fourth week of intervention, after sixth week of intervention and after eight week of intervention
Method of measurement
Fugl-Meyer assessment scale for Upper Extremity

2

Description
Activities of daily living and motor function of upper limb
Timepoint
At baseline, after second week of intervention, after fourth week of intervention, after sixth week of intervention and after eight week of intervention
Method of measurement
Motor activity log-28 scores

Intervention groups

1

Description
Intervention group:
Category
Rehabilitation

2

Description
Intervention group:
Category
Rehabilitation

Recruitment centers

1

Recruitment center
Name of recruitment center
Allied Hospital
Full name of responsible person
Ayesha Affi
Street address
Jail Road adjacent to Faisalabad Medical University, Near Sargodha Road, Faisalabad.
City
Faisalabad
Postal code
38800
Phone
+92 41 9210082
Fax
+92 41 9210079
Email
vcfmuf@gmail.com
Web page address
https://pmc.edu.pk/S-Result.aspx

2

Recruitment center
Name of recruitment center
District Headquarter Hospital
Full name of responsible person
Ayesha Affi
Street address
Mall Road, Faisalabad
City
Faisalabad
Postal code
38800
Phone
+92 41 9200140
Fax
+92 41 9200141
Email
vcfmuf@gmail.com
Web page address
https://www.businesslist.pk/company/189531/dhq-hospital-civil-hospital

3

Recruitment center
Name of recruitment center
Aziz Fatima Hospital
Full name of responsible person
Ayesha Affi
Street address
Gulistan Colony No. 1, Faisalabad.
City
Faisalabad
Postal code
38000
Phone
+92 41 87880910
Fax
+92 41 8862131
Email
marketing@afh.com.pk
Web page address
https://afmdc.edu.pk/

Sponsors / Funding sources

1

Sponsor
Name of organization / entity
The University of Faisalabad
Full name of responsible person
Ayesha Affi
Street address
Gulberg Road, St#1, H#p-14, opposite national Hospital, Faisalabad
City
Faisalabad
Postal code
37610
Phone
+92 316 7444844
Fax
+92 41 8868220
Email
ayesha.affi000@gmail.com
Grant name
Grant code / Reference number
Is the source of funding the same sponsor organization/entity?
Yes
Title of funding source
The University of Faisalabad
Proportion provided by this source
100
Public or private sector
Private
Domestic or foreign origin
Domestic
Category of foreign source of funding
empty
Country of origin
Type of organization providing the funding
Academic

Person responsible for general inquiries

Contact
Name of organization / entity
The University of Faisalabad
Full name of responsible person
Ayesha Affi
Position
Student
Latest degree
Bachelor
Other areas of specialty/work
Physiotherapy
Street address
Gulberg road, H#P14, St no1, jinnah colony, Faisalabad
City
Faisalabad
Province
Punjab
Postal code
38000
Phone
+92 41 8868326
Fax
+92 41 8750970
Email
2021-ms-pt-066@tuf.edu.pk

Person responsible for scientific inquiries

Contact
Name of organization / entity
The University of Faisalabad
Full name of responsible person
Ayesha Affi
Position
Student
Latest degree
Bachelor
Other areas of specialty/work
Physiotherapy
Street address
Gulberg road, H#P14, St no1, jinnah colony, Faisalabad
City
Faisalabad
Province
Punjab
Postal code
38000
Phone
+92 41 8868326
Fax
+92 41 8750970
Email
2021-ms-pt-066@tuf.edu.pk

Person responsible for updating data

Contact
Name of organization / entity
The University of Faisalabad
Full name of responsible person
Ayesha Affi
Position
Student
Latest degree
Bachelor
Other areas of specialty/work
Physiotherapy
Street address
Gulberg road, H#P14, St no1, jinnah colony, Faisalabad
City
Faisalabad
Province
Punjab
Postal code
38000
Phone
+92 41 8868326
Fax
+92 41 8750970
Email
2021-ms-pt-066@tuf.edu.pk

Sharing plan

Deidentified Individual Participant Data Set (IPD)
No - There is not a plan to make this available
Justification/reason for indecision/not sharing IPD
No further information
Study Protocol
Yes - There is a plan to make this available
Statistical Analysis Plan
Yes - There is a plan to make this available
Informed Consent Form
Yes - There is a plan to make this available
Clinical Study Report
Yes - There is a plan to make this available
Analytic Code
Undecided - It is not yet known if there will be a plan to make this available
Data Dictionary
Undecided - It is not yet known if there will be a plan to make this available
Title and more details about the data/document
Study Protocol Statistical Analysis Plan Informed Consent Form Clinical Study Report
When the data will become available and for how long
After six months
To whom data/document is available
To all the researchers and institutes
Under which criteria data/document could be used
Data will be shared for further clinical research
From where data/document is obtainable
Data will be shared through email addresses.
What processes are involved for a request to access data/document
After the publication of research
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