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Study aim
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This study aims to explore synergistic effects of Habe Asgand combined and isometric exercises interventions work together to improve physical function, reduce pain, and enhance the overall quality of life for individuals suffering from RA.
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Design
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Pragmatic, community based, parallel group, double blinded, randomised controlled trial. Total 70 patients will be randomised into three groups.
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Settings and conduct
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At Muhammad Institute of Medical and Allied Sciences Multan after getting approval from institutional ethical committee.
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Participants/Inclusion and exclusion criteria
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Inclusion: Adults (aged 25–60 years) diagnosed with rheumatoid arthritis (RA) based on ACR/EULAR 2010 classification criteria, Active disease symptoms with mild to moderate RA severity, Ability to follow an exercise regimen and adhere to treatment.
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Intervention groups
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Group A: will be given 1 tablet (500 mg) of Habb-e-Asgand, twice daily after meals, with lukewarm water for 12 weeks. Group B: will be treated with Isometric Exercise Intervention including quadriceps and hamstring isometric contractions (10-second holds, 10–15 repetitions per set), grip-strengthening exercises (squeezing a stress ball for 5–10 seconds, repeated 10–15 times).Each session lasts 30–40 minutes, with a focus on individual tolerance and gradual progression for 12 weeks.
Group C will be given combined Intervention both Habb-e-Asgand regimen and isometric exercise protocol as described above.
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Main outcome variables
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Pain, stiffness, physical activities will be main outcome variables. By using Western Ontario and McMaster Universities (WOMAC) and Numeric Pain Rating Scale , pain stiffness and activities of daily living will be assessed. erythrocyte sedimentation rate, C-reactive protein, rheumatoid factotr will also be monitored. X-ray will also be done for the assessment of the joints with rheumatoid arthritis.