Protocol summary

Study aim
The aim of the present study is to investigate the effect of corrective exercises with a systematic approach on the symptoms and complications of Upper Crossed Syndrome. (UCS).
Design
A randomized, single-blind, controlled clinical trial was conducted on 36 individuals
Settings and conduct
The measurements will be conducted in the Sports Science Laboratory of Arak University, and the training sessions will be carried out at the Diaphragm Corrective Exercises Center in Arak. Participants will be assessed during a pretest, a posttest, and a follow-up test over an approximate period of four months. The data collector and the statistical assessor will be blinded (single-blind).
Participants/Inclusion and exclusion criteria
The study participants will be 18-28 year-olds residing in Arak with Upper Crossed Syndrome and similar occupational characteristics. After initial screening and meeting the eligibility criteria, they will enroll in the study by providing written informed consent.
Intervention groups
The intervention group will perform a 12-week corrective exercise program using a systematic approach, three sessions per week, 60 minutes each. Sessions include warm-up, corrective, and cool-down phases. Based on Lederman’s neuromuscular adaptation theory and a stepwise model, the program targets dysfunctions in postural and movement control. Exercises will use Pilates balls, resistance bands, steps, weights, and Swedish ladders, under the supervision of a corrective exercise specialist following progressive overload principles. The control group will only engage in their usual daily activities.
Main outcome variables
Forward Head Angle, Forward Shoulder Angle, Thoracic Kyphosis Angle, Brain Electrical Activity, Muscle Electrical Activity, Range of Motion of Shoulder and Neck Joints, Static and Dynamic Balance

General information

Reason for update
Acronym
IRCT registration information
IRCT registration number: IRCT20250921067305N1
Registration date: 2025-11-12, 1404/08/21
Registration timing: retrospective

Last update: 2025-11-12, 1404/08/21
Update count: 0
Registration date
2025-11-12, 1404/08/21
Registrant information
Name
Mohamad Khorami Moghadam
Name of organization / entity
The University of Isfahan
Country
Iran (Islamic Republic of)
Phone
+98 86 3222 9722
Email address
m.khorami@spr.ui.ac.ir
Recruitment status
Recruitment complete
Funding source
Expected recruitment start date
2025-10-23, 1404/08/01
Expected recruitment end date
2025-11-01, 1404/08/10
Actual recruitment start date
empty
Actual recruitment end date
empty
Trial completion date
empty
Scientific title
The effect of corrective exercises with a systematic approach on brain oscillations, muscle activity, posture, range of motion, and balance in people with upper crossed syndrome.
Public title
Systematic approach in correction of upper crossed syndrome
Purpose
Supportive
Inclusion/Exclusion criteria
Inclusion criteria:
Individuals with upper crossed syndrome. Individuals with similar occupational characteristics. Individuals aged between 18–30 years. Having a Body Mass Index (BMI) between 18 and 25 kg/m². Eligibility for female participants requires regular menstruation and the absence of any menstrual conditions that may disrupt the research process.
Exclusion criteria:
Presence of any obvious malalignment in the pelvis or lower limbs, or any other musculoskeletal deformity. History of diseases related to the joints of the spine, shoulder, or pelvis. History of fracture or surgery. History of neurological or psychiatric disorders. Use of any medication affecting the central nervous system. Participation in any type of physical activity or sports that may influence the study outcomes. Having an angle greater than 5 degrees in the Adam’s test due to the possibility of scoliosis.
Age
From 18 years old to 28 years old
Gender
Both
Phase
N/A
Groups that have been masked
  • Outcome assessor
  • Data analyser
Sample size
Target sample size: 36
Randomization (investigator's opinion)
Randomized
Randomization description
The random allocation sequence will be generated using a block randomization method with an equal allocation ratio (1:1) and variable block sizes of 4 and 6. The random sequence will be created through a validated online randomization system (Sealed Envelope) under the supervision of an independent statistician. Both the block sizes and allocation sequence will remain concealed from the research team until the completion of participant enrollment to prevent allocation predictability. Allocation concealment will be achieved using sequentially numbered, opaque, and sealed envelopes. Each envelope will contain the code of the assigned group and will be stored in numerical order within a locked box. At enrollment, the registration officer, who is blinded to the randomization sequence, will open the next envelope in sequence and record the participant’s assigned group. The random sequence generation and envelope preparation will be carried out by an independent statistician, while participant enrollment and assignment will be performed by a separate researcher unaware of the allocation codes. Thus, the procedures for sequence generation, allocation concealment, and implementation are designed in accordance with CONSORT guidelines to minimize the risk of selection bias.
Blinding (investigator's opinion)
Single blinded
Blinding description
In this study, the following practical measures will be implemented to ensure effective blinding and minimize bias: Participants will be allocated to either the intervention or control group. The outcome assessor and the data analyst will remain blinded to the group allocation of the participants until the final analysis stage is fully completed. To guarantee this, the researcher administering the intervention, who is aware of the group assignments, will have no role in baseline data collection or outcome assessment. The collected raw data will be fully anonymized and coded before being handed over to the analyst, with group labels such as 1 and 2 replacing the actual group names.
Placebo
Not used
Assignment
Parallel
Other design features

Secondary Ids

empty

Ethics committees

1

Ethics committee
Name of ethics committee
research Ethics Committees of University of Isfahan
Street address
Isfahan University, Azadi Square, Isfahan
City
Isfahan
Province
Isfehan
Postal code
۸۱۷۴۶۷۳۴۴۱
Approval date
2025-05-31, 1404/03/10
Ethics committee reference number
IR.UI.REC.1404.053

Health conditions studied

1

Description of health condition studied
Upper Crossed Syndrome
ICD-10 code
R29.3
ICD-10 code description
Abnormal posture

Primary outcomes

1

Description
Forward head angle.
Timepoint
Outcome measure assessments will be conducted at three time points: before the initiation of the intervention, immediately following the 12-week intervention period, and finally, at a 4-week follow-up after the intervention concludes.
Method of measurement
The forward head will be measured using photogrammetry.

2

Description
Forward shoulder angle
Timepoint
Outcome measure assessments will be conducted at three time points: before the initiation of the intervention, immediately following the 12-week intervention period, and finally, at a 4-week follow-up after the intervention concludes.
Method of measurement
Forward shoulder angles will be measured using photogrammetry.

3

Description
Thoracic kyphosis angle.
Timepoint
Outcome measure assessments will be conducted at three time points: before the initiation of the intervention, immediately following the 12-week intervention period, and finally, at a 4-week follow-up after the intervention concludes.
Method of measurement
Kyphosis angle will be measured using a flexible ruler and the Formetric device.

4

Description
Brain electrical activity
Timepoint
Outcome measure assessments will be conducted at three time points: before the initiation of the intervention, immediately following the 12-week intervention period, and finally, at a 4-week follow-up after the intervention concludes.
Method of measurement
Brain activity will be recorded using an electroencephalography device.

5

Description
Trapezius muscles electrical activity
Timepoint
Outcome measure assessments will be conducted at three time points: before the initiation of the intervention, immediately following the 12-week intervention period, and finally, at a 4-week follow-up after the intervention concludes.
Method of measurement
The electrical activity of the muscles will be recorded using an electromyography device.

6

Description
Shoulder external rotation range of motion
Timepoint
Outcome measure assessments will be conducted at three time points: before the initiation of the intervention, immediately following the 12-week intervention period, and finally, at a 4-week follow-up after the intervention concludes.
Method of measurement
Range of motion will be assessed using a universal goniometer.

7

Description
Shoulder flexion range of motion
Timepoint
Outcome measure assessments will be conducted at three time points: before the initiation of the intervention, immediately following the 12-week intervention period, and finally, at a 4-week follow-up after the intervention concludes.
Method of measurement
Range of motion will be assessed using a universal goniometer.

8

Description
Neck flexion range of motion
Timepoint
Outcome measure assessments will be conducted at three time points: before the initiation of the intervention, immediately following the 12-week intervention period, and finally, at a 4-week follow-up after the intervention concludes.
Method of measurement
Range of motion will be assessed using a universal goniometer.

9

Description
Static balance
Timepoint
Outcome measure assessments will be conducted at three time points: before the initiation of the intervention, immediately following the 12-week intervention period, and finally, at a 4-week follow-up after the intervention concludes.
Method of measurement
Static balance will be assessed using a pressure distribution platform.

10

Description
Dynamic balance
Timepoint
Outcome measure assessments will be conducted at three time points: before the initiation of the intervention, immediately following the 12-week intervention period, and finally, at a 4-week follow-up after the intervention concludes.
Method of measurement
Dynamic balance will be measured using the Y Balance Test.

Secondary outcomes

empty

Intervention groups

1

Description
Intervention Group: The experimental group will participate in a 12-week corrective exercise program based on a systematic approach. The training will be conducted three times per week, with each session lasting 60 minutes. Each session will consist of a 10-minute warm-up, 45 minutes of corrective exercises, and a 5-minute cool-down phase involving stretching and manual techniques performed by a corrective exercise specialist. In this approach, the human body is considered an integrated system, aiming to correct the underlying causes of dysfunction across the subsystems involved in posture and movement control, either simultaneously or sequentially. In this study, to address upper crossed syndrome, 144 diverse exercise patterns with a unified purpose will be employed, grounded in Lederman’s neuromuscular adaptation theory and implemented through a stepwise model. The training model will progress through the following stages: Correction of breathing pattern and core stability, Correction of range of motion, Correction of muscle activation patterns, Correction of basic movements, Correction of fundamental movement patterns, Correction of functional movement patterns, And finally, maintenance of the achieved posture through exercises aimed at improving physical fitness and motor performance. During the sessions, equipment such as Pilates balls, resistance bands, steps, weights, and Swedish ladders will be utilized. All exercises will be performed under the direct supervision of a corrective exercise specialist, following the principles of progressive overload and individualized training.
Category
Lifestyle

2

Description
Control Group: Participants in the control group will be instructed to refrain from participating in any structured exercise programs and to maintain their usual daily physical activities throughout the study duration.
Category
N/A

Recruitment centers

1

Recruitment center
Name of recruitment center
Arak university
Full name of responsible person
Zohreh Babaei
Street address
Faculty of Sport Sciences, Arak University, Karbala Ave, Basij Sauer, Arak
City
Arak
Province
Markazi
Postal code
۳۸۴۸۱۷۷۵۸۴
Phone
+98 86 3222 1722
Email
zobabaeii@gmail.com

Sponsors / Funding sources

1

Sponsor
Name of organization / entity
The University of Isfahan
Full name of responsible person
Dr. Babbak Saffari
Street address
The university of Isfahan , Azadi Square, Isfahan
City
Isfahan
Province
Isfehan
Postal code
۸۱۷۴۶۷۳۴۴۱
Phone
+98 31 3793 2171
Email
b_saffari@ase.ui.ac.ir
Web page address
https://research.ui.ac.ir/%D9%85%D8%B9%D8%A7%D9%88%D9%86-%D9%BE%DA%98%D9%88%D9%87%D8%B4-%D9%88-%D9%81%D9%86%D8%A7%D9%88%D8%B1%DB%8C
Grant name
Grant code / Reference number
Is the source of funding the same sponsor organization/entity?
Yes
Title of funding source
The University of Isfahan
Proportion provided by this source
100
Public or private sector
Public
Domestic or foreign origin
Domestic
Category of foreign source of funding
empty
Country of origin
Type of organization providing the funding
Academic

Person responsible for general inquiries

Contact
Name of organization / entity
The university of Isfahan
Full name of responsible person
Mohamad Khorami Moghadam
Position
Ph.D. Candidate
Latest degree
Master
Other areas of specialty/work
Sport Medicine
Street address
No. 6, Laleh 2, Shekh Mofid Ave, Arak
City
Arak
Province
Markazi
Postal code
3816137667
Phone
+98 86 3222 9722
Email
m.khorami@hotmailm.com

Person responsible for scientific inquiries

Contact
Name of organization / entity
The University of Isfahan
Full name of responsible person
Mohamad Khorami Moghadam
Position
Ph.D. candidate
Latest degree
Master
Other areas of specialty/work
Sport Medicine
Street address
No 6, laleh 2, Sheykh Mofid Ave, Arak
City
Arak
Province
Isfehan
Postal code
3816137667
Phone
+98 86 3222 9722
Fax
Email
m.khorami@spr.ui.ac.ir

Person responsible for updating data

Contact
Name of organization / entity
The University of Isfahan
Full name of responsible person
Mohamad Khorami Moghadam
Position
Ph.D. candidate
Latest degree
Master
Other areas of specialty/work
Sport Medicine
Street address
No 6, laleh 2, Sheykh Mofid Ave, Arak
City
Arak
Province
Isfehan
Postal code
3816137667
Phone
+98 86 3222 9722
Fax
Email
m.khorami@spr.ui.ac.ir

Sharing plan

Deidentified Individual Participant Data Set (IPD)
Yes - There is a plan to make this available
Study Protocol
Yes - There is a plan to make this available
Statistical Analysis Plan
Yes - There is a plan to make this available
Informed Consent Form
Yes - There is a plan to make this available
Clinical Study Report
Yes - There is a plan to make this available
Analytic Code
Not applicable
Data Dictionary
Not applicable
Title and more details about the data/document
Individual-level data will be made available after de-identifying the study participants. This data will include demographic characteristics, recorded EEG data, electromyographic (EMG) data, as well as data related to posture measurement, balance, and range of motion. It is noteworthy that all data will be made available after applying the necessary statistical adjustments.
When the data will become available and for how long
The data access period will commence six months after the publication of the study's results.
To whom data/document is available
Access to the research data will be restricted to researchers affiliated with academic and scientific institutions.
Under which criteria data/document could be used
Performing statistical analyses within the scope of published articles related to the present research is permissible. However, the misuse of data to extract new findings is strictly prohibited.
From where data/document is obtainable
Applicants can submit their requests via the Telegram application to the postal address and contact number provided below. Postal Email: M.khorami@hotmail.com Telegram: +98 936 360 8888
What processes are involved for a request to access data/document
The applicant must provide a compelling and specific justification for requesting the data. Upon receipt of the request, they will be notified that their application is under review. Following approval by the research team, the data will be made available to the applicant within one month from the start of the request review.
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