Inclusion criteria:
Individuals must be 18 years of age or older.
must have a history of painful anal fissure (AF) for three months (90 days) or longer prior to screening
No history of diabetes
Presence of a radial fissure with indurated edges observed on anorectal examination
Presence of either anterior or posterior anal fissure
Presence of a skin tag observed during anorectal examination
For individuals who have been using other topical medications, a washout period of at least two weeks prior to the start of the study will be required.
Exclusion criteria:
Individuals who are unwilling to undergo AF examination involving the anal canal or perianal region.
Individuals who have undergone lateral sphincterotomy, anal dilation, or any previous interventions
the anal canal or perianal region.Individuals who have used glyceryl trinitrate (GTN) ointment for more than one week during the 4 weeks prior to the screening visit, within a 6-month period.
Anal fissure associated with other conditions (e.g., trauma, HIV infection, fistula, inflammatory bowel disease, perianal sepsis, or malignancy).
Individuals who are expected to undergo another treatment plan requiring hospitalization during the study.
History of cardiovascular disease, inflammatory bowel disease, chronic fecal incontinence, prior pelvic radiotherapy, fixed anal stenosis/fibrosis, major psychiatric disorders (including cigarette, drug, or alcohol users), or hematologic .
Use of investigational drugs within 8 weeks or a period equal to five half-lives prior to screening, whichever is longer.
diseases Individuals who may be unavailable during the trial period, are unlikely to comply with the protocol, or are otherwise deemed unsuitable by the physician for any reason.