Evaluation of the Effectiveness of Fractional CO₂ Laser Alone Versus Combined Fractional CO₂ Laser and Q-Switched Long-Pulsed 1064 nm Laser in Hand Rejuvenation

Evaluation of the Effectiveness of Fractional CO₂ Laser Alone Versus Combined Fractional CO₂ Laser and Q-Switched Long-Pulsed 1064 nm Laser in Hand Rejuvenation

This study is a split-body randomized clinical trial in which each patient serves as their own internal control. In each individual, one arm is randomly assigned to receive fractional CO₂ laser and Q-Switched Long-Pulsed Nd:YAG 1064 nm laser, and the other arm is assigned to fractional CO₂ laser. Treatment assignment is performed using a simple randomization method in Excel software, and results are reported by dermatologists according to treatment type.

This is a randomized split-body clinical trial in which each participant receives Fractional Carbon Dioxide laser treatment in one hand and a combination of Fractional Carbon Dioxide laser and Q-Switched Long-Pulsed Neodymium-Doped Yttrium Aluminum Garnet 1064 nm laser in the contralateral hand. Treatments are performed in three sessions with 4 to 6-week intervals, and outcomes are evaluated by a blinded assessor at predefined follow-up time points.

Exclusion criteria include active hand skin diseases, abnormal scarring history, use of photosensitizing drugs, pregnancy or lactation, psychiatric disorders or poor compliance, recent laser or similar treatments within six months, systemic or autoimmune diseases affecting wound healing, and severe photosensitivity or hypersensitivity to treatment materials.

In this group, the allocated hand will receive combination therapy with Fractional Carbon Dioxide laser and Q-Switched Long-Pulsed Neodymium-Doped Yttrium Aluminum Garnet 1064 nm laser.

Overall hand skin rejuvenation improvement

Several dermatologists, blinded to the type of laser used on each hand (CO₂ alone versus CO₂ combined with Q-switched laser), will offer their assessments concerning the comparison of the two hands

All data is potentially shareable after de-identifying individuals.

Access period starts 1 year after results are published.

Our data will only be available to researchers working in academic and scientific institutions.

The data and documentation of this study will be used solely for scientific and research analysis within the framework of the approved goals of the project.

Hassan Sharifian Darcheh ۹۸۹۱۳۶۷۷۷۴۳۳

Submitting a Formal Request: The applicant must send an official written request via the university’s institutional email to the principal investigator. The request should clearly state the purpose of use, the specific data required, and the intended application. Preliminary Review: Upon receiving the request, the principal investigator will review it for consistency with the study’s objectives and ethical considerations. If necessary, the request will be discussed with other members of the research team. Ethical Approval: If the applicant seeks access to raw or individual-level data, a valid ethical approval from an authorized ethics committee must be provided. Without such approval, data access will not be granted. Confidentiality Agreement: Once the request is approved, the applicant will be required to sign a confidentiality agreement, committing to use the data only for the declared purpose and to refrain from sharing it with unauthorized parties. Data Preparation and Anonymization: Prior to data sharing, all datasets will be anonymized and coded to ensure the confidentiality of participants. Data Delivery: The data will be delivered as an encrypted file through the official university email. Depending on the scope and volume of the request, the review and delivery process typically takes 10 to 20 working days