Comparative study of intravenous administration of low-dose Propofol with lidocaine on the reduction of local pain caused by intravenous injection of full-dose Propofol during induction of general anesthesia

Comparison of low-dose intravenous of Propofol and Lidocaine on the reduction of local pain caused by intravenous injection of full-dose Propofol during anesthesia induction.

This randomized, double-blind, parallel-group, phase 2-3 clinical trial will be conducted on 88 patients 18 to 60 years who are candidates for elective surgery under general anesthesia using a block randomization.

In operating room, after fixing a 20G angiocatheter in the veins on the back of the patient's hand, the hand is held up for 10 seconds and a tourniquet is tied at the top of the angiocatheter and one of two drugs, propofol and lidocaine, is injected in syringes of the same volume and shape. After 2 minutes, the vein is opened and 0.5 mg/kg propofol is injected and the intensity of hand 's pain is recorded based on the VAS. Then the rest of the propofol (1.5 mg/kg) is injected along with the other induction drugs, and the patient is then intubated.

Inclusion:18-60 years; ASA class1&2; Elective surgery under general anesthesia.Exclusion: Cardiovascular disease; Seizures;Use of narcotics and sedatives; Food and drug allergies; Infection or wounds on the back of the hands.

In operating room, after fixing a 20G angiocatheter in the veins on the back of the patient's hand, the hand is held up for 10 seconds and a tourniquet is tied at the top of the angiocatheter. Then, one of the two drugs, lidocaine (40 mg) or propofol (20 mg), is injected. After 2 minutes, the vein is opened and 0.5 mg/kg propofol is injected. Then, the intensity of pain in the patient's hand during the injection of propofol is recorded based on the VAS. Finally, anesthesia is induced by injecting the rest of the propofol (1.5 mg/kg) and the other drugs, and intubation will be performed after 3 minutes.

Intensity of hand pain

In this study, we will use the quadruple Block Randomization method. For this purpose, we prepare four sheets of paper.Write the letter A on two sheets and the letter B on the other two sheets. Mix the sheets together and place them in the desk drawer. With the referral of each eligible patient, one of the sheets is randomly taken out and based on this sheet is A or B, it will be assigned to one of the two groups of Propofol or Lidocaine. After randomly pulling out all four sheets, all the papers are returned to the drawer and the above procedure will be continued for the next four patients until the desired sample size is reached.

After inserting a size 20 angiocatheter into the patient's hand and receiving 5ml/kg of Ringer's solution, the patient's hand will be held up for 10 seconds, then the top of the angiocatheter will be blocked with a tourniquet, and on the randomization block, one of two drugs, Lidocaine (40 mg) or Propofol (20 mg), will be injected by the anesthesiologist. in syringes of the same shape and volume, covered with cloth tape, and numbered by the nurse anesthetist (who is unaware of the details of the design).