Study aim: Evaluation of the effectiveness of physician communication training on level of patient’ health literacy skills and hypertension outcome among patients with uncontrolled blood pressure. Design: A randomized controlled trial method was used to enroll 242 hypertensive patients and 35 physicians from healthcare clinics in the Mashhad, Iran. All participants received a code, then, they were randomly divided into two control and intervention groups. Multiple statistical analysis were used to assess whether the physician training improved physicians-patient's communication skills, hypertension outcomes, self- efficacy, and patient medication adherence after intervention. Settings and conduct: The study population was women and men who referred to health centers in Mashhad, Iran. 6 Clinics were randomly assigned (as the unit of randomization) to either usual care control (n = 3 clinics) or the training intervention (n = 3). Participants/Inclusion and exclusion criteria: They have uncontrolled blood pressure, age 18 or older, could speak and read Farsi، able to give informed consent, did not suffered an acute-myocardial infarction or had kidney disease and other health impairments Intervention groups: All participants were allocated into an educational intervention group and control group. In intervention group, the educational intervention was conducted based on the potential communication gaps with focus on Health Literacy in Practice (HLP) strategies. The control group did not receive any intervention education. Main outcome variables: Hypertension outcomes; physicians-patient's communication skills; Self- efficacy; patient medication adherence