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Study aim: The effect of vitamin D supplementation and aerobic exercise on serum concentrations of inflammatory factors and pulmonary function in male smokers Design: The study was a phase 2, community-based and pragmatic, randomized, no blinding, controlled clinical trial on 40 subjects, and a sealed envelope was used for randomization. Settings and conduct: The subjects of the vitamin D supplement + aerobic exercise group and the aerobic exercise group ran for 4 weeks (3 days a week) with an intensity of more than 50% of the maximum heart rate in Tabriz Stadium. In addition, subjects in the vitamin D supplement group + aerobic exercise and the vitamin D supplement group received vitamin D 1000 units per week for four weeks. Also, the control group did not have any activity or supplementation during 4 weeks of intervention. Participants/Inclusion and exclusion criteria: Inclusion criteria: having at least one year of smoking history and being healthy. Exclusion criteria: having clinical diseases Intervention groups: Intervention group: 10 male smokers who did aerobic exercise for 4 weeks (running at more than 50% of maximum heart rate, 3 days a week) and at the same time taking vitamin D supplement (6000 units per week). Intervention group: 10 male smokers who did aerobic exercise for 4 weeks (running at more than 50% of maximum maximum heart rate, 3 days a week). Intervention group: 10 male smokers who took vitamin D supplement (6000 units per week) for 4 weeks. Control group: did not have any activity or supplementation during 4 weeks of intervention. Main outcome variables: Tumor necrosis factor alpha (TNF-α), Interleukin-6 (IL-6), Clara protein (CC16), Surfactant-D protein (SP-D) and Lung function
IRCTID: IRCT20180513039637N4
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