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Study aim: A Comparison between the Effect of Empagliflozin and Pioglitazon on Echocardiographic Indexes in Patients with Type 2 Diabetes and Nonalcoholic Fatty Liver Disease Design: Randomized, double-blind, Parallel-group, phase II clinical trial in 70 patients. Randomization was done through block randomization method. Settings and conduct: Type 2 Diabetic patients with nonalcoholic fatty liver are referred to Firoozgar hospital will be randomized to two groups (A,B) and in the groups Empagliflozin and Pioglitazone will be prescribed with same coverage and researcher, patients and data analyzer will be blind to type of the drug. Participants/Inclusion and exclusion criteria: Inclusion criteria : Type 2 diabetes mellitus (T2DM); HbA1C between 7-10.5%; NAFLD with cap score >300 dB/m ;Normal Ejection Fraction (EF≥50%). Non-inclusion criteria: Ischemic or non Ischemic heart disease ;Current use of SGLT2 inhibitors; Current use of Thiazolidendions ;Hepatitis B; Hepatitis C; Autoimmune Hepatitis; Alcohol consumption more than 30 gr/day in men; Alcohol consumption more than 20 gr/day in women; eGFR<45 cc/min/1.73 m2. Intervention groups: Intervention group 1: 35 patients with type 2 diabetes and NAFLD will be treated with Empagliflozin 10 milligram, once daily for 24 weeks. Intervention group 2: 35 randomized patients with type 2 diabetes and NAFLD will be treated with Pioglitazone 30 milligram, once daily for 24 weeks. Main outcome variables: Echocardiographic Indices
IRCTID: IRCT20190122042450N5
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