Evaluation of efficacy of intra articular injection of mannitol versus hypertonic dextrose prolotherapy on decreasing pain and improvement of functions in patients with knee osteoarthritis

Evaluation of efficacy of intra articular injection of mannitol versus hypertonic dextrose prolothrapy on decreasing pain and improvement of function in patients with knee osteoarthritis randomize clinical trial

The research is a randomize triple blind clinical trial

The patient select from emam reza clinic and rajaee hospital who has knee osteoarthritis.then patient divided into two groups and after obtaining written consent the study begins. in control group hypertonic dextrose is injected and in intervention group monitol is injected then we measure its effect on reducing pain and improving patient function

Inclusion criteria :age : 38 to75 years old Gender: male or female Knee radiography anterior standing view have been for the last one month Have symptoms of osteoarthritis include pain, crepitation and knee joint dryness for at least a month without any extra articular involvement .Any injection of the knee joint during the last three of months Exclusion criteria: sensitivity reaction to test drug The patient have done total knee arthroplasty The patient have diseases mimicking the symptoms of knee pain such as neuropathy and radiculopathy Diseases such as rheumatoid arthritis, Reiter's syndrom, gout Uncontrolled diabetes,HBA1c more than7.5, BMI more than 40 History of knee trauma,fracture Patient's mental disorder

Intervention group:group that receive knee intra articular injection of mannitol control group: group that receive knee intra articular injection of hypertonic Dextrose.

pain, Activity of daily living

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Complete randomize block design with SSPP software is used for randomization and then sealed non-transparent envelopes are used to hide the random sequence

Participant: The participant is explained that if they are interested, they can join our research project. two methods used to reduce patient pain input study are explained to the patient. Benefits and possible complications of both methods are described to the patient and the patient is told to randomly fall into one of the intervention groups. If the patient is accepted to admit the study, by random allocation soft ware, the patient falls in to one of two groups. Clinical car giver: we teach the caregiver how to complete the questionnaier. This person is not aware of receiving patient intervention. Researcher: In this study does not have the ability to blind the reseacher because the researcher performs both intervention himself and is aware of receiving each intervention in the group. The outcome assessor of the complete questionnaires is given to person who is not aware of the interventions performed and he/she is asked to determine the level of performance in each person according to the questionnaires. Date analyzer: questionnaire are finally given to a person to review the information. This person doesn't know any of the steps of the work, how to classify and the intervention performed.

All available data can be shared after making people unidentifiable.

Start access period one year after publishing the results.

everyone can access to this information.

if the information in this study helps to improve the science process.

dr.nasrin.barzegar1975@gmail.com 00989173092357

After sending the desired message, all authors of the study will be consulted all information will be sent within a maximum of three weeks if permitted.