Comparative analysis of Proprioceptive Exercises with and without Topical Glucosamine Sulfate on Pain and Functional Disability in Knee Osteoarthritis

The basic purpose of this research is to compare the effects of Proprioceptive exercises with and without topical glucosamine sulfate on knee osteoarthritis in reducing pain and functional disability.

The randomized controlled trial, single-blinded study.

conducted at Muhammad physical therapy clinic and rehabilitation centre, Multan and Faiz Hospital, Multan, Pakistan,

Inclusion criteria: age 45-70 years, bilateral knee OA (grade 1,2 and 3), both genders (male and female), cartilage degeneration, local biomechanical factors (e.g., joint deformity, muscle weakness), nutritional factors, postmenopausal women, and Exclusion criteria: grade 4, neurological disorders (e.g. Alzheimer’s disease, Parkinson’s disease), knee replacement, rheumatoid arthritis, steroidal injection in the past 2 months, neuropathy, tumor, knee fractures, knee ligament or meniscus injury, a congenital disorder of knee, diabetes mellitus > 10 years, metal implants in the knee. Intervention groups

control group-A and treatment group-B. Group-A was treated with proprioceptive exercises while group-B was treated with proprioceptive exercises with glucosamine sulfate gel

Pain functional activity

Allocation concealment occurs and patients will be recruited by using simple randomization through the Lottery method. lottery method carried out through sealed envelopes. Each participant will randomly choose the sealed envelope and open this sealed envelope.

In a double-blinded study, participants and investigators will be blinded. Participants will be unaware of the type of treatments that will receive and the investigator will be unaware of the type of treatment on which group which intervention will be given and for what purpose that be evaluated after the completion of the intervention trial. subjects will choose between two samples. both the samples are in the same packing. In one sample, glucosamine sulfate gel with proprioceptive exercises i.e., standing on 1 leg [eyes open and closed], knee flexion and extension exercises [sitting position with a chair and TheraBand], Walking on heel and toes [forward, backward, left, right, carioca crossover with eyes open and closed], Half squat on soft ground, Side lunge, One-legged balance exercise. In another sample, an aqueous gel with no effects for the satisfaction of subjects and proprioceptive exercises i.e., Standing on 1 leg [eyes open and closed], Knee flexion and extension exercises [sitting position with a chair and TheraBand], Walking on heel and toes [forward, backward, left, right, carioca crossover with eyes open and closed], Half squat on soft ground, Side lunge, One-legged balance exercise will be given. Subjects and investigators will be completely unaware of the type and effects of both interventions.

Demographic data and data related to final outcome will be shared by maintaining the confidentiality

data will be available from Feb 2023 to March 2023 after the 6 months of publication. The data sharing plan for a clinical trial (i.e., what data will be shared when and under what conditions) will be publicly available at a third-party site that shares data with and meets the data requirements of WHO's International Clinical Trials Registry Platform; this occur before the first participant is enrolled.

Hifza Arif(corresponding author) Senior lecturer at Ali-Ul-Murtaza Department of Rehabilitation Sciences and Muhammad Institute of Medical and Allied Sciences Multan, Pakistan

For research purposes

To the corresponding author of the study; Dr. Hifza Arif and can contact on +923097697428 hifzaa630@gmail.com can visit these search engines, you can find my study easily here https://www.researchgate.net/ https://scholar.google.com/

open-access and There is the traditional public data release where anyone can get access to the data with no registration or conditions. The request will be reviewed by Director in Charge and in case of eligibility, it would be shared in two weeks.

I want randomized controlled trial registration.