the Comparative study effect of Dexmedetomidine and Ketamine on post operative analgesia after laparoscopic cholecystectomy surgery

study effect of Dexmedetomidine and Ketamine on post operative analgesia after laparoscopic cholecystectomy surgery

Clinical trial with control group, with parallel groups, double-blind, randomized, phase 2 on 252 patients, rand function of Excel software was used for randomization.

This study will be conducted as a double-blind clinical trial on (252) patients in 1402-1403 in Imam Hospital of Ahvaz-Iran after obtaining permission from the Ethics Committee of Jundishapur University of Ahvaz on patients who undergo laparoscopic cholecystectomy surgery. After visiting the operating room and initial examinations, the patients will have an intravenous line .Initial monitoring will include pulse oximetry, non-invasive sphygmomanometer, and electrocardiography. Initial hemodynamic parameters such as heart rate and blood pressure will be recorded upon arrival, immediately after receiving the study drugs, every 5 minutes to 15 minutes, and then every 15 minutes until the end of the procedure. In the following, the hemodynamic parameters and duration of analgesia (VAS score) in 24, 12, 6, 1 hours after surgery

inclusion criteria : patients with ASA class I and II, patient age between 18 and 50 years.Exclusion criteria : emergency surgery, sensitivity to drugs used in the study, abuse or alcohol, lack of consent to participate in the study, psychiatric disorders

Patients are randomly divided into three groups (ketamine, dexmedetomidine and control).Group K: In this group, 0.5 mg/kg/h of ketamine is injected intravenously 15 minutes before surgical incision. Group D: In this group, 0.6 µ/kg/min dexmedetomidine is injected intravenously 15 minutes before surgical incision. Group C: In this group, normal saline is injected intravenously.

Post operative pain control

People were divided into two groups completely randomly based on the random block permutation method. For example, for blocks of four, we imagined 6 blocks ABBA, AABB, ABAB, BABA, BBAA, BAAB, which should be n/4 We sampled from these blocks in the form of placement. The random sequence was obtained from the website www.sealedenevelope.com. Patients are entered in the order of entry.Patients are randomly divided into three groups (ketamine, dexmedetomidine and control).Group: K In this group, 0.5 mg/kg/h of ketamine (Panpharma, Germany) is injected intravenously 15 minutes before surgical incision. Group: D In this group, 0.6 µ/kg/min dexmedetomidine (Exir Company, Iran) is injected intravenously 15 minutes before surgical incision

the patient and the anesthesia technician are unware of the type of injected drug.the medicine is already prepare and given to the technician

Only part of the data, such as information about the main outcome or the like, can be shared.

The access period starts 6 months after the results are published

It will be available only to researchers working in academic and scientific institutions.

Researcher's request to conduct similar studies

Request by sending an email to the responsible administrator

Sending an email to the responsible executive and explaining the procedure, then sending the data to her