The effect of 6-week high intensity interval training using an exercise snack training on cardiometabolic and renal indicators in overweight/obese adults
Investigating the effect of 6 weeks of high-intensity interval training in the form of exercise snacks on cardiometabolic and renal markers in overweight/obese adults
Design
A randomized, single‑blinded, parallel‑group, controlled clinical trial on 60 patients. For randomization, opaque sealed envelopes will be used.
Settings and conduct
Study setting: Payame Noor University, Alborz Province, Karaj Branch; study population: overweight or obese adults; type of blinding: laboratory technicians will not be aware of the group allocation when assessing blood samples.
Participants/Inclusion and exclusion criteria
Inclusion Criteria: Participants were eligible for inclusion if they were sedentary and physically inactive, overweight or obese adults of both sexes with a body mass index of 25 kg/m² or greater, aged 35 to 55 years, in general good health or free from any serious illness or unstable condition requiring medical supervision over diet or physical activity, and without any physical limitations or restrictions.
Exclusion Criteria: pregnancy, being currently adhering to a structured weight-loss program or using weight-loss medications, failed to obtain physician approval for study participation.
Intervention groups
Intervention Group 1: HIIT2; performing 2 bouts of high-intensity interval training per day with intervals of 1–4 hours apart, 3 days per week.
Intervention Group 2: HIIT6; performing 6 bouts of high-intensity interval training per day with intervals of 1–4 hours apart, 3 days per week.
Control Group: C; no training.
The effect of 6-week high intensity interval training using an exercise snack training on cardiometabolic and renal indicators in overweight/obese adults
Public title
The effect of an exercise training period on cardiometabolic and renal markers in overweight/obese adults
Purpose
Supportive
Inclusion/Exclusion criteria
Inclusion criteria:
Sedentary and physically inactive adults
Overweight or obese individuals
Body mass index (BMI) ≥ 25 kg/m²
Both men and women
Aged 35–55 years
In generally good health
Free from any serious illness or unstable medical condition requiring physician supervision over diet or physical activity
No physical limitations or restrictions affecting exercise participation
Exclusion criteria:
Having acute cardiovascular disease
Following specific dietary regimes
With weight instability (+_5 kg) in the past 3 months
Having any serious medical condition that precludes long-term participation in physical activity
Pregnancy
Currently adhering to a structured weight-loss program
Using weight-loss medications
Failure to obtain physician approval for study participation
Age
From 35 years old to 55 years old
Gender
Both
Phase
N/A
Groups that have been masked
Outcome assessor
Sample size
Target sample size:
60
Randomization (investigator's opinion)
Randomized
Randomization description
Simple randomization will be used for participant allocation. To ensure concealment, a series of opaque, sealed envelopes will be prepared. For this purpose, envelopes labeled with the name of either the exercise intervention group or the control group will be created, corresponding to the total number of subjects. After thoroughly mixing (shuffling) the envelopes, each participant will select one, and their group assignment will be recorded accordingly
Blinding (investigator's opinion)
Single blinded
Blinding description
Clinical laboratory technicians, unaware of the group allocation, will assess the blood parameters.
The ratio of high-density lipoprotein to low-density lipoprotein
Timepoint
24–48 hours before and after the intervention
Method of measurement
By means of the formula
9
Description
Thyroid-Stimulating Hormone
Timepoint
24–48 hours before and after the intervention
Method of measurement
By ELISA or enzymatic laboratory method
10
Description
Thyroxine
Timepoint
24–48 hours before and after the intervention
Method of measurement
By ELISA or enzymatic laboratory method
11
Description
Bilirubin
Timepoint
24–48 hours before and after the intervention
Method of measurement
By ELISA or enzymatic laboratory method
12
Description
Urea
Timepoint
24–48 hours before and after the intervention
Method of measurement
By ELISA or enzymatic laboratory method
13
Description
Uric acid
Timepoint
24–48 hours before and after the intervention
Method of measurement
By ELISA or enzymatic laboratory method
14
Description
Creatinine
Timepoint
24–48 hours before and after the intervention
Method of measurement
By ELISA or enzymatic laboratory method
15
Description
estimated Glomerular Filtration Rate
Timepoint
24–48 hours before and after the intervention
Method of measurement
By ELISA or enzymatic laboratory method
Secondary outcomes
1
Description
Systolic blood pressure
Timepoint
24–48 hours before and after the intervention
Method of measurement
Using a German Beurer device
2
Description
Diastolic blood pressure
Timepoint
24–48 hours before and after the intervention
Method of measurement
Using a German Beurer device
3
Description
Resting heart rate
Timepoint
24–48 hours before and after the intervention
Method of measurement
Using a German Beurer device
4
Description
Mean arterial pressure
Timepoint
24–48 hours before and after the intervention
Method of measurement
Using the formula
5
Description
Body Mass Index
Timepoint
24–48 hours before and after the intervention
Method of measurement
Using the formula
6
Description
Waist-to-hip circumference ratio
Timepoint
24–48 hours before and after the intervention
Method of measurement
Using the formula
7
Description
Waist-to-height ratio
Timepoint
24–48 hours before and after the intervention
Method of measurement
Using the formula
8
Description
Body weight
Timepoint
24–48 hours before and after the intervention
Method of measurement
Scale
9
Description
height
Timepoint
24–48 hours before the intervention
Method of measurement
Wall-mounted height measure
10
Description
Wall squat test
Timepoint
24–48 hours before the intervention
Method of measurement
By recording the duration
11
Description
30-Second Chair Stand Test
Timepoint
24–48 hours before the intervention
Method of measurement
By counting the repetitions
12
Description
Quality of Life
Timepoint
24–48 hours before the intervention
Method of measurement
Questionnaire
Intervention groups
1
Description
Control group: Control group participants are to remain inactive throughout the study and are advised to follow their usual daily routines.
Category
Other
2
Description
Intervention group 1: Two-Bout High-Intensity Interval Training: The training protocol includes 2 bouts of exercise, each containing 4 sets of 2-minute body-weight HIIT exercises at 85% of maximal heart rate (HRmax). Each set is interspersed with 1 minute and 30 seconds of active recovery (at 65% HRmax) between successive sets.
Category
Rehabilitation
3
Description
Intervention group 2: Six-Bout High-Intensity Interval Training: The training protocol includes 6 exercise bouts, each containing 2 sets of 80-second body-weight HIIT exercises at 85% of maximal heart rate (HRmax). Each set is interspersed with 1 minute of active recovery (at 65% HRmax) between successive sets.
Category
Rehabilitation
Recruitment centers
1
Recruitment center
Name of recruitment center
Payame Noor University, Alborz Province, Karaj Branch