Study aim: to compare effect of calorie restriction compared with no calorie restriction on blood pressure and plasma BDNF levels in overweight / obese patients undergoing stable treatment with antihypertensive drugs Design: This is a parallel, non-blind, randomized clinical trial. In this study, participants who are eligible will be selected. Individuals are randomly assigned to one of two groups. The sequence of assigning individuals to the study groups is done using Random Allocation Software. Settings and conduct: Overweight / obese people who regularly take high blood pressure medications are randomly assigned to one of two groups of low-calorie or regular non-calorie-restricted diets. The duration of the study will be 2 months. Patients with high blood pressure who are not calorie restricted are given general advice on daily consumption of vegetables, fruits and reducing salt intake. In both groups of calorie restriction, first the daily caloric requirement is calculated using the appropriate equation and coefficient of physical activity, and then about 500 calories are deducted from it, and the low-calorie diet using the substitution list method and the inclusion of all food groups Is set. Participants/Inclusion and exclusion criteria: Inclusion: • BMI>25 • age 40-70 • Regular use of antihypertensive drugs for at least the last 3 months • non-smoker • haven't been under any weight-loss diet at least 3 months before participating in the study Exclusion: • Taking antipsychotic, anticonvulsant drugs • Cancer or chronic kidney disease stage 4-5 • Any changes in the disease treatment plan during the study, including changes in the type and dose of drugs used to affect blood pressure or surgery • Pregnancy or breastfeeding • Insulin treated patients • Taking omega 3 supplement Intervention groups: -Low-calorie diet -Routine normal diet of the participants Main outcome variables: Blood pressure