The aim of the study is to explore the effects of the raw extracts of the herbs asafetida and fennel on polycystic ovary syndrome (PCOS). The study is a triple-blind randomized clinical trial. The study population consists of female students aged 15-30 years who complain of oligomenorrhea and obtain a score of at least 8 on Ferriman–Gallwey questionnaire. The subjects who are not willing to participate in the study, or have used medication over the past three months, or have participated in a similar study are excluded.
Materials and methods: 45 of the participants whose hirsutism scores according to Ferriman–Gallwey questionnaire were 8 or above underwent sonography for determination of their ovarian morphology. In addition, blood samples were taken for measurement of their sex hormones. Subsequently, the 45 participants were randomly divided into three groups to receive one of the three interventions of placebo, asafetida and fennel for two months, twice daily. At the end of the interventions, the participants' degrees of hirsutism were re-evaluated using Ferriman–Gallwey questionnaire and the sonography and blood sample collection were repeated.
IRCT registration information
IRCT registration number:IRCT2016040427207N1
Registration date:2016-11-12, 1395/08/22
Name of organization / entity
Jahrom University of Medical Sciences
Iran (Islamic Republic of)
Dr Kavous Solhju: Vice Chancellor for Research
Expected recruitment start date
Expected recruitment end date
Actual recruitment start date
Actual recruitment end date
Trial completion date
Effect of Ferrula assa foetida and Fennle on improving PCOs women who refer to clinic
Effect of Ferrula assa foetida and Fennle on improving PCOs
student girls aged 15-30 years were complained of oligo/amenorrhea; hirsutism score ≥8 based on Ferriman-Galway scale.
Exclusion criteria: history of medical treatment from 3 months age; participation in another study; no willing to participate in this study.