Comparison of The Effect of Taking Oxygen with Not Taking Oxygen in the Prognosis of Patients with Acute Myocardial Infarction

The main aim is to compare the effect of oxygen with non-oxygen on the prognosis of patients with acute myocardial infarction.

In this project, a randomized trial will be performed based on the evaluation of supplemental oxygen versus air in patients with AMI who were not initially hypoxic. This random sampling will be done from a computer catalogue using an online random model. Oxygen saturation is recorded at the beginning and end of treatment.

The study areas are all Zahedan educational hospitals. The study includes patients aged 30 years or older who came to the emergency or cardiac intensive care by ambulance or by themself. During this research, evaluations are provided to the research team without the information of the study group. Descriptive statistics are used to describe the data, standard deviation, frequency and percentage. The comparison and difference between the results of oxygen therapy in patients with myocardial infarction are determined by chi-square test. The T-test is used to compare the average time of patients' hospitalizations. The p-value (>0.05) is considered to show the statistical difference. All analyses are performed with SPSS software.

Inclusion criteria: - Patients who have symptoms suggestive of MI - ECG changes with elevated cardiac troponin - Oxygen saturation of 90% or higher on pulse oximetry Exclusion criteria: - Patients who have continuous oxygen therapy - Patients who have suffered cardiac arrest prior to inclusion - If supplemental oxygen therapy is started before evaluation for inclusion for less than 20 minutes

Patients are randomly selected to receive oxygen through an oral mask (6 litres per minute for the next 6 to 12 hours) or room air.

Effect of supplemental oxygen versus air in patients with AMI

In this method, based on the sample size, we will prepare a number of envelopes whose contents are not known at all, and then on the cards, random sequences that have been generated online through the randomization website for random allocation. We put them in envelopes. Now the concealment must be done on the method used to execute the random sequence on the participants. So that before the assignment of each person, his / her assigned group is not known. Without this, there is a possibility of disclosing the sequences, which will weaken the research. On the other hand, it can lead to the elimination of certain patients based on their prognosis, or patients with better conditions enter the intervention group and patients with worse conditions. Be the control group and cause the selection bias in the study as a whole. Therefore, it is necessary to make a decision to participate or reject the study from the beginning and fill in the informed consent forms and then the participants are randomly assigned to each group. In the implementation of the random allocation process, what is important is the person who performs this process, who should not be in other stages of this research and should be separate from other researchers in order to reduce possible bias.

All types of data (related to changes of oxygen therapy in acute myocardial infarction) will be published as anonymous for each planned publication.

The data will be available six months after publishing the first draft of data analysis and results in national and international journals and conferences.

All sorts of findings and data analyses for future academic and industrial researchers.

It may be necessary to use these research findings to write-up future research on this topic. Therefore, by maintaining the anonymity of the patients, the findings are available for other researchers.

They should be in touch with Mahsa Zeiasaeidi as chief investigator of this research via mahsa.zsd@zaums.ac.ir.

There is a need to contact Mahsa Zeiasaeidi (chief investigator of this research) via email. She will share all available data to the inquirer within less than six months.